PMID- 12392858
OWN - NLM
STAT- MEDLINE
DCOM- 20030411
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 11
DP  - 2002 Nov
TI  - A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian 
      populations of African, South Asian, and mixed ancestry.
PG  - 1045-54
AB  - Using polymerase chain reaction-sequence-specific primer (PCR-SSP) typing, this 
      study determined the frequency of human leukocyte antigen (HLA) DR- and -DQ 
      alleles and haplotypes in individuals of African (n = 75), South Asian (n = 98), 
      and mixed (n = 102) ancestry from the Caribbean island of Trinidad. We detected 
      19 different haplotypes containing DRB3, 8 containing DRB4, 6 containing DRB5, 
      and 6 different haplotypes without DRB3/4/5 genes. Twenty-nine haplotypes were 
      identified in Africans, 24 in the South Asians, and 32 in the mixed group. We 
      detected significant differences between the populations, principally at the DQA1 
      and DQB1 loci, although the allele frequency for DRB1*0901 was highest in the 
      Africans (p(c) < 0.05). Trinidad African and mixed groups were generally more 
      diverse than the South Asians and displayed a wider range of DRB1-DQB1 
      associations; DQB1*02 and DQB1*0301 each associated with five to six different 
      DRB1 alleles in the Africans and mixed group but only two in South Asians. In the 
      Africans and the mixed group, DQB1*04 was found with DRB1*0302 and DRB1*04, but 
      only with DRB1*08 in the South Asians. Trinidad Africans revealed consistencies 
      with populations in Western, Central, and Northern Africa, but differed 
      considerably from individual populations on the African continent. Trinidad South 
      Asians displayed similar allele frequencies and associations to other populations 
      from Northern India.
FAU - Carrington, Christine V F
AU  - Carrington CV
AD  - Department of Pre-Clinical Sciences, Faculty of Medical Sciences, University of 
      the West Indies, St. Augustine, Trinidad. ccarrington@fmx.uwi.tt
FAU - Kondeatis, Elli
AU  - Kondeatis E
FAU - Ramdath, D Dan
AU  - Ramdath DD
FAU - Norman, Paul J
AU  - Norman PJ
FAU - Vaughan, Robert W
AU  - Vaughan RW
FAU - Stephens, Henry A F
AU  - Stephens HA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asia/ethnology
MH  - Black People
MH  - *Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Trinidad and Tobago
EDAT- 2002/10/24 04:00
MHDA- 2003/04/12 05:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/04/12 05:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - S0198885902004378 [pii]
AID - 10.1016/s0198-8859(02)00437-8 [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Nov;63(11):1045-54. doi: 10.1016/s0198-8859(02)00437-8.