PMID- 12393039
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20190922
IS  - 0385-8146 (Print)
IS  - 0385-8146 (Linking)
VI  - 29
IP  - 4
DP  - 2002 Oct
TI  - Globus sensation caused by gastroesophageal reflux disease.
PG  - 347-51
AB  - OBJECTIVES: This study was designed to examine whether or not gastro esophageal 
      reflux disease (GERD) is implicated in globus sensation. METHODS: The subjects 
      were 25 patients (16 men/9 women; mean age: 51, range 25-69 years) complaining of 
      globus sensation with one or more of four laryngeal findings suspected of having 
      GERD, such as pooling of saliva, erythema of posterior one-third of larynx, 
      inter-arytenoids edema, and granuloma. All 25 patients were administrated a 
      proton pump inhibitor (PPI) for a period of 8 weeks. All were given esophageal 
      endoscopies, laryngoscopes, and questionnaire before and after PPI dosing. The 
      questionnaire survey was conducted to investigate changes in globus sensation and 
      three symptoms specific to GERD including heartburn, regurgitation, and belching. 
      Subjective symptoms were totalled by the over all scores of the three subjective 
      symptoms which served as an index of severity of GERD. RESULTS: Fifty-two percent 
      (13/25) of patients had reflux esophagitis. The esophagitis were improved after 
      PPI administration except one case. The incidences of GERD symptoms were high 
      (heart burn 68% (17/25), belching 49% (10/25) and regurgitation 76% (19/25)), and 
      most of these symptoms ameliorated by PPI administration. The laryngeal findings 
      were improved in all patients. Subjective symptoms were improved in 68% (17/25) 
      of globus patients. The improvement rate of total score (before PPI dosing/after 
      PPI dosing) was compared between the two groups: one with improved globus 
      sensation (17 patients) and the other without (8 patients). The improvement rate 
      was significantly higher in the group with improved globus sensation (P<0.05). 
      This means that globus sensation improved because of the improvement in GERD. 
      CONCLUSION: GERD is therefore concluded to be an inducing factor of globus 
      sensation.
FAU - Tokashiki, Ryoji
AU  - Tokashiki R
AD  - Department of Otorhinolaryngology, Tokyo Medical University, 6-7-1 
      Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan. tokachanman@aol.com
FAU - Yamaguchi, Hiroya
AU  - Yamaguchi H
FAU - Nakamura, Kazuhiro
AU  - Nakamura K
FAU - Suzuki, Mamoru
AU  - Suzuki M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Proton Pumps)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Eructation/etiology
MH  - Female
MH  - Gastroesophageal Reflux/*complications/diagnosis/drug therapy
MH  - Heartburn/etiology
MH  - Humans
MH  - Laryngoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors
MH  - Proton Pumps/therapeutic use
MH  - Sensation Disorders/diagnosis/*etiology
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2002/10/24 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - S0385814602000226 [pii]
AID - 10.1016/s0385-8146(02)00022-6 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2002 Oct;29(4):347-51. doi: 10.1016/s0385-8146(02)00022-6.