PMID- 12394532 OWN - NLM STAT- MEDLINE DCOM- 20021220 LR - 20191106 IS - 1095-0680 (Print) IS - 1095-0680 (Linking) VI - 18 IP - 3 DP - 2002 Sep TI - Electroconvulsive stimuli alter the regional concentrations of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in adult rat brain. PG - 138-43 AB - In this study we investigated whether electroconvulsive stimuli (ECS) altered the regional brain protein concentrations of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) in Sprague Dawley rats. Electroconvulsive stimuli were administered once daily for 8 days. At the end of the experiment, rats were killed, the brains were dissected into five regions, and the neurotrophic factors were extracted and measured by enzyme-linked immunosorbent assay. Electroconvulsive stimuli increased the concentrations of NGF in the frontal cortex and concentrations of BDNF in the hippocampus, the striatum, and the occipital cortex. In contrast, ECS decreased GDNF concentrations in the hippocampus and the striatum. Our data indicate that neurotrophic factors play a role in the mechanism of action of ECS and, by extrapolation, may play a role in the mechanism of action of electroconvulsive treatment. FAU - Angelucci, Francesco AU - Angelucci F AD - Karoliniska Institutet, Institution of Physiology and Pharmacology, Division of Pharmacology and Institution of Clinical Neuroscience, Stockholm, Sweden. FAU - Aloe, Luigi AU - Aloe L FAU - Jimenez-Vasquez, Patricia AU - Jimenez-Vasquez P FAU - Mathe, Aleksander A AU - Mathe AA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J ECT JT - The journal of ECT JID - 9808943 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Gdnf protein, rat) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Animals MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - *Electroshock MH - Enzyme-Linked Immunosorbent Assay MH - Glial Cell Line-Derived Neurotrophic Factor MH - Male MH - Nerve Growth Factor/*metabolism MH - Nerve Growth Factors/*metabolism MH - Osmolar Concentration MH - Rats MH - Rats, Sprague-Dawley MH - Regression Analysis MH - Tissue Distribution EDAT- 2002/10/24 04:00 MHDA- 2002/12/21 04:00 CRDT- 2002/10/24 04:00 PHST- 2002/10/24 04:00 [pubmed] PHST- 2002/12/21 04:00 [medline] PHST- 2002/10/24 04:00 [entrez] AID - 10.1097/00124509-200209000-00005 [doi] PST - ppublish SO - J ECT. 2002 Sep;18(3):138-43. doi: 10.1097/00124509-200209000-00005.