PMID- 12396479
OWN - NLM
STAT- MEDLINE
DCOM- 20030304
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 11
IP  - 4
DP  - 2002 Aug
TI  - Interleukin-18 and CD30 serum levels in patients with moderate-severe depression.
PG  - 265-7
AB  - Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role 
      in the T-cell-helper type 1 response, is a new member of the family of cytokines 
      produced in the brain. CD30 is a marker of T-cell-helper type 2 lymphocytes. We 
      evaluated IL-18 and CD30 serum levels in 10 patients affected by moderate-severe 
      depression (MSD). We demonstrated for the first time that serum IL-18 levels of 
      MSD patients were significantly higher than those of healthy donors. On the 
      contrary, no significant difference was found between serum CD30 levels of MSD 
      patients compared with those of healthy donors. These data strengthen the 
      hypothesis that MSD disease is associated with an inflammatory response, mainly 
      T-cell-helper type 1, and suggest an important role for IL-18 in the 
      pathophysiology of MSD.
FAU - Merendino, Rosaria Alba
AU  - Merendino RA
AD  - Chair of Immunopathology, Department of Human Pathology, University of Messina 
      Medical School, University Hospital G. Martino, 98125 Messina, Italy.
FAU - Di Rosa, Antonio Enrico
AU  - Di Rosa AE
FAU - Di Pasquale, Giuseppe
AU  - Di Pasquale G
FAU - Minciullo, Paola Lucia
AU  - Minciullo PL
FAU - Mangraviti, Carmela
AU  - Mangraviti C
FAU - Costantino, Antonella
AU  - Costantino A
FAU - Ruello, Antonella
AU  - Ruello A
FAU - Gangemi, Sebastiano
AU  - Gangemi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Interleukin-18)
RN  - 0 (Ki-1 Antigen)
SB  - IM
MH  - Adult
MH  - Depression/blood/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Ki-1 Antigen/*blood
MH  - Middle Aged
PMC - PMC1781663
EDAT- 2002/10/25 04:00
MHDA- 2003/03/05 04:00
PMCR- 2002/08/01
CRDT- 2002/10/25 04:00
PHST- 2002/10/25 04:00 [pubmed]
PHST- 2003/03/05 04:00 [medline]
PHST- 2002/10/25 04:00 [entrez]
PHST- 2002/08/01 00:00 [pmc-release]
AID - 10.1080/096293502900000131 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2002 Aug;11(4):265-7. doi: 10.1080/096293502900000131.