PMID- 12397680
OWN - NLM
STAT- MEDLINE
DCOM- 20021218
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 60
IP  - 10
DP  - 2002 Oct
TI  - [Angiotensin II receptor and oxidative stress].
PG  - 1893-7
AB  - Angiotensin II(AngII) activates NADH/NAPDH oxidase activity and stimulates 
      reactive oxygen species(ROS) production, which induces many proinflammatory genes 
      such as vascular cell adhesion molecule-1(VCAM-1), intercellular adhesion 
      molecule-1 (ICAM-1), and monocyte chemoattractant protein-1(MCP-1) mainly via 
      AngII type I receptor(AT1). ROS are important in cardiovascular disease because 
      many of these preinflammatory cytokines play a critical role in the initiation 
      and progression of atherosclerosis. AT1 receptor blockade is important to prevent 
      cardiovascular disease. AngII type 1 receptor blocker(ARB) and/or AngII 
      converting enzyme inhibitor(ACEI) are useful for preventing cardiovascular 
      disease. The role of AngII type II receptor(AT2) for producing ROS and/or 
      cardiovascular damage has been studied.
FAU - Usui, Makoto
AU  - Usui M
AD  - Department of Cardiovascular Medicine, Kyushu University Faculty of Medicine.
FAU - Egashira, Kensuke
AU  - Egashira K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Receptors, Angiotensin)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Oxidative Stress/*physiology
MH  - Receptors, Angiotensin/*physiology
RF  - 20
EDAT- 2002/10/26 04:00
MHDA- 2002/12/19 04:00
CRDT- 2002/10/26 04:00
PHST- 2002/10/26 04:00 [pubmed]
PHST- 2002/12/19 04:00 [medline]
PHST- 2002/10/26 04:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2002 Oct;60(10):1893-7.