PMID- 12398236
OWN - NLM
STAT- MEDLINE
DCOM- 20030409
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 25
IP  - 9
DP  - 2002 Oct
TI  - Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 
      diabetes mellitus.
PG  - 779-84
AB  - Autoimmune thyroiditis is often associated with Type 1 diabetes mellitus (T1DM). 
      In non-obese adult-onset diabetes diagnosed initially as Type 2 diabetes mellitus 
      (T2DM), there is a proportion of cases with so far undiagnosed T1DM. The 
      objective of this study was to estimate the frequency of autoimmune thyroiditis 
      (AT) among non-obese (BMI <30.0 kg/m2) patients with T2DM and to compare the 
      frequency of AT in subgroups of patients according to the presence of glutamic 
      acid decarboxylase antibodies (GADA), insulin requirement, and post-breakfast 
      C-peptide levels. The study included 118 adult patients (55 men and 63 women) 
      with the initial diagnosis of T2DM and age at the onset of diabetes > 35 yr. 
      Median of age was 66 yr (range 39-82), and median duration of diabetes was 9 
      (range 1-27) yr. AT was diagnosed using thyroid peroxidase antibodies, 
      TG-antibodies, US and TSH levels. Nineteen per cent of the subjects were found to 
      have AT, and the frequency of AT did not significantly differ between the groups 
      of GADA+ and GADA- subjects. There was no difference in the frequency of AT 
      between the group treated with hypoglycemic agents and/or diet and the group 
      requiring insulin. The frequency of AT was higher in the group with 
      post-breakfast C-peptide levels < or = 0.8 nmol/l compared to the group with 
      post-breakfast C-peptide levels > 0.8 nmol/l (37% vs 16%), however the group with 
      post-breakfast C-peptide levels < or = 0.8 nmol/l had longer duration of 
      diabetes.
FAU - Matejkova-Behanova, M
AU  - Matejkova-Behanova M
AD  - Institute of Endocrinology, Prague, Czech Republic. mbehanova@endo.cz
FAU - Zamrazil, V
AU  - Zamrazil V
FAU - Vondra, K
AU  - Vondra K
FAU - Vrbikova, J
AU  - Vrbikova J
FAU - Kucera, P
AU  - Kucera P
FAU - Hill, M
AU  - Hill M
FAU - Andel, M
AU  - Andel M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Autoantibodies)
RN  - 0 (C-Peptide)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - EC 1.4.1.2 (Glutamate Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/analysis
MH  - C-Peptide/blood
MH  - Diabetes Mellitus, Type 2/*complications/diet therapy/drug therapy
MH  - Female
MH  - Glutamate Dehydrogenase/immunology
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Incidence
MH  - Insulin/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period
MH  - Thyroiditis, Autoimmune/*complications/*epidemiology
EDAT- 2002/10/26 04:00
MHDA- 2003/04/10 05:00
CRDT- 2002/10/26 04:00
PHST- 2002/10/26 04:00 [pubmed]
PHST- 2003/04/10 05:00 [medline]
PHST- 2002/10/26 04:00 [entrez]
AID - 5835 [pii]
AID - 10.1007/BF03345512 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2002 Oct;25(9):779-84. doi: 10.1007/BF03345512.