PMID- 12398910
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 453
IP  - 2-3
DP  - 2002 Oct 25
TI  - MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects 
      on serotonin transporter densities.
PG  - 239-44
AB  - Low levels of serotonin may reduce the density of the serotonin transporter 
      (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive 
      response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced 
      reductions in SERT density could be related to such a mechanism, 
      p-chlorophenylalanine or MDMA was administered to rats, and brain serotonin and 
      SERT density were measured. As expected, both treatments led to serotonin 
      depletion 1, 7 and 14 days later. However, only MDMA reduced SERT density. This 
      observation suggests that MDMA-induced reductions in SERT density do not 
      represent neuroadaptive responses to decreased levels of brain serotonin, but may 
      occur in response to some other stimulus or to the neurotoxic effects of MDMA.
FAU - Boot, Brendon P
AU  - Boot BP
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Johns 
      Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
FAU - Mechan, Annis O
AU  - Mechan AO
FAU - McCann, Una D
AU  - McCann UD
FAU - Ricaurte, George A
AU  - Ricaurte GA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Retracted Publication
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, rat)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
RIN - Ricaurte GA. Eur J Pharmacol. 2004 Apr 5;489(1-2):1. PMID: 15063148
RIN - Eur J Pharmacol. 2006 Dec 28;553(1-3):304. PMID: 17176514
MH  - Animals
MH  - Autoradiography
MH  - Brain/drug effects/metabolism
MH  - Carrier Proteins/*metabolism
MH  - Cerebellar Cortex/drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Fenclonine/*pharmacology
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - *Membrane Transport Proteins
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - *Nerve Tissue Proteins
MH  - Paroxetine/pharmacology
MH  - Radioligand Assay
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Plasma Membrane Transport Proteins
EDAT- 2002/10/26 04:00
MHDA- 2003/07/09 05:00
CRDT- 2002/10/26 04:00
PHST- 2002/10/26 04:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2002/10/26 04:00 [entrez]
AID - S0014299902024202 [pii]
AID - 10.1016/s0014-2999(02)02420-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2002 Oct 25;453(2-3):239-44. doi: 10.1016/s0014-2999(02)02420-2.