PMID- 12399129
OWN - NLM
STAT- MEDLINE
DCOM- 20030429
LR  - 20190922
IS  - 0169-5002 (Print)
IS  - 0169-5002 (Linking)
VI  - 38
IP  - 2
DP  - 2002 Nov
TI  - Blood vessel invasion in resected non small cell lung carcinomas is predictive of 
      metastatic occurrence.
PG  - 169-76
AB  - Prognosis of patients with non small cell lung cancer (NSCLC) remains difficult 
      to assess, even after adjustment for pathological stage. Prognostic value of 
      numerous biological markers has been evaluated, with conflicting results. Data of 
      86 patients with NSCLC treated by surgery were collected with clinical 
      characteristics, histopathological data including tumor differentiation and 
      status of blood and lymphatic vessel invasion and evaluation by 
      immunohistochemistry of Rb, Bcl-2 and Ki-67 expression. Prognostic values for 
      overall survival (OS) and event-free survival (EFS) were analyzed by the log tank 
      test and the multivariable Cox model. Using univariable analyses, pT, pN, poor 
      differentiation or large cell subtype were associated with a poor OS, while 
      lymphatic and/or blood vessel invasion were associated with a short EFS. None of 
      the molecular markers had a significant prognostic value for either outcome. In 
      multivariable analyses, only stage remained of prognostic value for OS. 
      Interestingly, the presence of blood vascular invasion in the tumor was 
      significantly predictive for subsequent metastatic occurrence in stages I and II. 
      This feature might, therefore, be relevant for administration of adjuvant therapy 
      in completely resected NSCLC.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Rigau, V
AU  - Rigau V
AD  - Service d'Anatomie et de Cytologie Pathologiques, Hotel-Dieu, 1 place du Parvis 
      Notre-Dame, 75181 Paris Cedex 04, France.
FAU - Molina, T J
AU  - Molina TJ
FAU - Chaffaud, C
AU  - Chaffaud C
FAU - Huchon, G
AU  - Huchon G
FAU - Audouin, J
AU  - Audouin J
FAU - Chevret, S
AU  - Chevret S
FAU - Brechot, J M
AU  - Brechot JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*blood supply/*pathology
MH  - Cell Differentiation
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood supply/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Metastasis
MH  - Neoplasm Staging/*methods
MH  - *Neovascularization, Pathologic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2002/10/26 04:00
MHDA- 2003/04/30 05:00
CRDT- 2002/10/26 04:00
PHST- 2002/10/26 04:00 [pubmed]
PHST- 2003/04/30 05:00 [medline]
PHST- 2002/10/26 04:00 [entrez]
AID - S0169500202002131 [pii]
AID - 10.1016/s0169-5002(02)00213-1 [doi]
PST - ppublish
SO  - Lung Cancer. 2002 Nov;38(2):169-76. doi: 10.1016/s0169-5002(02)00213-1.