PMID- 1239978
OWN - NLM
STAT- MEDLINE
DCOM- 19760324
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 8
IP  - 6
DP  - 1975 Dec
TI  - Comparison of the antiviral effects of 5-methoxymethyl-deoxyuridine with 
      5-iododeoxyuridine, cytosine arabinoside, and adenine arabinoside.
PG  - 643-50
AB  - The antiviral activity of 5-methoxymethyl-2'-deoxyuridine (MMUdR) was compared 
      with that of 5-iodo-2'-deoxyuridine (IUdR), cytosine arabinoside (Ara-C), and 
      adenine arabinoside (Ara-A). At concentrations of 2 to 4 mug/ml, MMUdR was 
      inhibitory to herpes simplex virus type 1, but concentrations as high as 128 
      mug/ml were not inhibitory to three other herpesviruses tested (equine 
      rhinopneumonitis virus, murine cytomegalovirus, and feline rhinopneumonitis 
      virus) or to vaccinia virus. The other nucleosides, in contrast, were inhibitory 
      at similar concentrations (1 to 8 mug/ml) against all viruses tested. The 
      inhibition of HSV-1 by MMUdR appeared to be the result of interference with virus 
      replication rather than the result of drug toxicity to host cells. The drug was 
      not toxic to host cells at 100 times the antiviral concentrations, and 
      pretreatment of host cells with high concentrations of MMUdR had no effect on 
      subsequent virus replication. Combination of MMUdR with either IUdR, Ara-A, or 
      Ara-C gave an enhanced antiviral effect, suggesting that the mechanism of action 
      of MMUdR is different from that of the other three drugs. Antiviral indexes were 
      calculated for each compound and were found to be >250, 80, 40, and 8 for MMUdR, 
      IUdR, Ara-A, and Ara-C, respectively. These were defined as the minimum dose at 
      which toxicity was observed microscopically divided by the dose which reduced 
      plaque numbers by 50%.
FAU - Babiuk, L A
AU  - Babiuk LA
FAU - Meldrum, B
AU  - Meldrum B
FAU - Gupta, V S
AU  - Gupta VS
FAU - Rouse, B T
AU  - Rouse BT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antiviral Agents)
RN  - 0 (Purine Nucleosides)
RN  - 04079A1RDZ (Cytarabine)
RN  - FA2DM6879K (Vidarabine)
RN  - LGP81V5245 (Idoxuridine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Cats
MH  - Cell Line
MH  - Cytarabine/*pharmacology
MH  - Deoxyuridine/*analogs & derivatives/pharmacology
MH  - Herpesviridae/*drug effects
MH  - Humans
MH  - Idoxuridine/*pharmacology
MH  - Mice
MH  - Purine Nucleosides/*pharmacology
MH  - Rabbits
MH  - Vaccinia virus/*drug effects
MH  - Vidarabine/*pharmacology
PMC - PMC429441
EDAT- 1975/12/01 00:00
MHDA- 1975/12/01 00:01
PMCR- 1975/12/01
CRDT- 1975/12/01 00:00
PHST- 1975/12/01 00:00 [pubmed]
PHST- 1975/12/01 00:01 [medline]
PHST- 1975/12/01 00:00 [entrez]
PHST- 1975/12/01 00:00 [pmc-release]
AID - 10.1128/AAC.8.6.643 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1975 Dec;8(6):643-50. doi: 10.1128/AAC.8.6.643.