PMID- 12399962
OWN - NLM
STAT- MEDLINE
DCOM- 20021202
LR  - 20220309
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 16
IP  - 11
DP  - 2002 Nov
TI  - Leukemic dendritic cells: potential for therapy and insights towards immune 
      escape by leukemic blasts.
PG  - 2197-204
AB  - Dendritic cells (DCs) are a system of potent antigen-presenting cells (APCs) 
      specialized to initiate primary immune responses. DCs are considered important 
      elements in the induction of specific antitumor cytotoxic effectors. At present, 
      because of potential therapeutic implications, the critical role of DCs in cancer 
      patients is under intensive investigation. Interactions between DCs and acute 
      myeloid leukemia cells represent an attractive model for the study of DC 
      physiology. Moreover, DCs can be a valuable therapeutic tool for the adjuvant 
      treatment of leukemic patients. However, DC subsets in vivo may also be affected 
      by leukemogenesis and may contribute to the escape of leukemia from immune 
      control. The aim of this review is to shed further light on this paradoxical 
      picture where the line between immune tolerance and immune defense is narrow.
FAU - Mohty, M
AU  - Mohty M
AD  - Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Universite de la 
      Mediterranee, Marseille, France.
FAU - Olive, D
AU  - Olive D
FAU - Gaugler, B
AU  - Gaugler B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Antigens, Neoplasm
MH  - Cancer Vaccines/*therapeutic use
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology/pathology
MH  - Humans
MH  - Immunotherapy
MH  - Leukemia/*immunology/*therapy
MH  - T-Lymphocytes, Cytotoxic/*immunology
RF  - 149
EDAT- 2002/10/26 04:00
MHDA- 2002/12/03 04:00
CRDT- 2002/10/26 04:00
PHST- 2002/02/13 00:00 [received]
PHST- 2002/05/30 00:00 [accepted]
PHST- 2002/10/26 04:00 [pubmed]
PHST- 2002/12/03 04:00 [medline]
PHST- 2002/10/26 04:00 [entrez]
AID - 10.1038/sj.leu.2402710 [doi]
PST - ppublish
SO  - Leukemia. 2002 Nov;16(11):2197-204. doi: 10.1038/sj.leu.2402710.