PMID- 12400611
OWN - NLM
STAT- MEDLINE
DCOM- 20030312
LR  - 20190816
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 43
IP  - 8
DP  - 2002 Aug
TI  - A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute 
      lymphoblastic leukemia.
PG  - 1673-7
AB  - Complex chromosomal abnormalities are rare in adult patients with acute 
      lymphoblastic leukemia (ALL). Using molecular methods, we characterized a complex 
      karyotype involving chromosomes 3, 6, 11, 12, and 22 in a 38-year-old man with 
      ALL. Cytogenetic analysis revealed the following karyotype: 
      46,XY,der(3)t(3;?6)(q22;?p21), - 6,add(11)(q23),add(12)(p13), + 
      mar[10]/46,XY[19]. Because patients with 11q23 abnormalities have a poor 
      prognosis and require aggressive treatment, we used fluorescence in situ 
      hybridization (FISH) to fully characterize the abnormalities. FISH analysis 
      showed no rearrangement of the MLL or ETV6-CBFA2 (TEL-AML1) genes; the wild-type 
      ETV6 allele was deleted in most cells. The revised karyotype after the FISH 
      analysis was as follows: 
      46,XY,der(3)t(3;12)(p13;p?13)del(3)(q21),der(6)inv(6)(p21q21)ins(6;3)(q21;q21q25),der(11)t 
      (3; 11)(q25;q23),der(12)t(11; 12)(q23;p?12),t(12;22)(p13;q13). Although 
      structural abnormalities involving 11q23 and 12p13 bands were identified by 
      conventional cytogenetics, this report clearly demonstrates that molecular assays 
      are needed to fully characterize gene rearrangements, complex translocations as 
      well as to assign patients to the appropriate treatment group.
FAU - Shivakumar, Subramaniyam
AU  - Shivakumar S
AD  - Department of Hematology, Christian Medical College Hospital, Vellore, Tamil 
      Nadu, India.
FAU - Mathew, Susan
AU  - Mathew S
FAU - Dalton, James
AU  - Dalton J
FAU - Chandy, Mammen
AU  - Chandy M
FAU - Srivastava, Alok
AU  - Srivastava A
LA  - eng
GR  - CA-20180/CA/NCI NIH HHS/United States
GR  - CA-21765/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 3
MH  - *Chromosomes, Human, Pair 6
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA-Binding Proteins/genetics
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Oncogene Proteins, Fusion/genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
EDAT- 2002/10/29 04:00
MHDA- 2003/03/13 04:00
CRDT- 2002/10/29 04:00
PHST- 2002/10/29 04:00 [pubmed]
PHST- 2003/03/13 04:00 [medline]
PHST- 2002/10/29 04:00 [entrez]
AID - 10.1080/1042819021000003018 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2002 Aug;43(8):1673-7. doi: 10.1080/1042819021000003018.