PMID- 12402004
OWN - NLM
STAT- MEDLINE
DCOM- 20021120
LR  - 20170214
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 127
IP  - 4
DP  - 2002 Oct
TI  - Hepatocyte growth factor/scatter factor stimulates mitogenesis and migration of a 
      head and neck squamous cell carcinoma cell line.
PG  - 271-8
AB  - OBJECTIVE: We sought to assess the effect of extracellular matrix and hepatocyte 
      growth factor/scatter factor (HGF/SF) on the growth and motility of cultured 
      squamous cell carcinoma of the head and neck (SCCHN) cells. METHODS: Cultured 
      cells were incubated in the presence of HGF/SF. The effect of HFG/SF on cell 
      growth, motility, and phosphorylation of the signaling proteins FAK and Erk was 
      determined. RESULTS: HGF/SF is both mitogenic and motogenic to the human SCCHN 
      cell line FaDu. Incubation of FaDu cells in the presence of HGF/SF led to a rapid 
      increase in phosphorylation of both FAK and the growth-promoting kinase Erk. 
      HGF/SF-induced phosphorylation of FAK and Erk was observed in both detached and 
      attached SCCHN cells. However, phosphorylation was much greater in attached 
      cells. CONCLUSIONS AND SIGNIFICANCE: The mitogenic and motogenic activities of 
      HGF/SF may contribute to the pathogenesis of SCCHN in vivo.
FAU - Fleigel, Jeffery
AU  - Fleigel J
AD  - Department of Otolaryngology, University of Florida College of Medicine, 
      Gainesville 32610, USA.
FAU - Sedwick, Jack
AU  - Sedwick J
FAU - Kornberg, Lori J
AU  - Kornberg LJ
LA  - eng
GR  - 503CA085132-02/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Carcinoma, Squamous Cell/pathology/physiopathology
MH  - Cell Division/drug effects
MH  - Cell Movement/*drug effects
MH  - Extracellular Matrix
MH  - Head and Neck Neoplasms/pathology/physiopathology
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Humans
MH  - Phosphorylation/drug effects
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Tumor Cells, Cultured
EDAT- 2002/10/29 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/29 04:00
PHST- 2002/10/29 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/29 04:00 [entrez]
AID - S0194599802000931 [pii]
AID - 10.1067/mhn.2002.127414 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2002 Oct;127(4):271-8. doi: 10.1067/mhn.2002.127414.