PMID- 12402135
OWN - NLM
STAT- MEDLINE
DCOM- 20030425
LR  - 20131121
IS  - 0017-8470 (Print)
IS  - 0017-8470 (Linking)
VI  - 53
IP  - 11
DP  - 2002 Nov
TI  - [ANCA-positive vasculitis of the skin and kidneys associated with acne 
      conglobata].
PG  - 730-4
AB  - A 19 year old man with severe acne conglobata and ulcerated pyoderma 
      gangraenosum-like skin lesions on the face was first treated with isotretinoin 
      (Roaccutan((R))), then immunosuppressively with prednisolone, 
      diaminodiphenylsulfone (Dapson-Fatol((R))) and mycophenolate mofetil 
      (Cellcept((R))). Under a daily maintenance dose of immunosuppressive treatment 
      with 2.5 mg prednisolone and 1 g mycophenolate mofetil, weakness, muscle and 
      joint aches appeared. Due to proteinuria, haematuria and an elevated 
      antineutrophil cytoplasmic antibody (cANCA) and the histological detection of a 
      leukocytoclastic vasculitis, the diagnosis of cANCA positive vasculitis of the 
      skin and kidneys was established. Therapy with cyclophosphamide (Endoxan((R))) 
      along with prednisolone was effective. An exact classification of this disease 
      process was not possible.
FAU - Manz, B
AU  - Manz B
AD  - Klinik und Poliklinik fur Hautkrankheiten der Universitat Leipzig, Germany. 
      BernMa@gmx.de
FAU - Rytter, M
AU  - Rytter M
FAU - Mittag, M
AU  - Mittag M
FAU - Seidel, W
AU  - Seidel W
FAU - Nenoff, P
AU  - Nenoff P
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - cANCA-positive Vaskulitis der Haut und Nieren im Verlauf einer Acne vulgaris 
      conglobata.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunosuppressive Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Acne Vulgaris/drug therapy/*immunology/pathology
MH  - Adult
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Cyclophosphamide/therapeutic use
MH  - Diagnosis, Differential
MH  - Drug Therapy, Combination
MH  - Endothelium, Vascular/immunology/pathology
MH  - Facial Dermatoses/drug therapy/*immunology/pathology
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/therapeutic use
MH  - Isotretinoin/adverse effects/therapeutic use
MH  - Kidney/*blood supply
MH  - Male
MH  - Neutrophils/immunology/pathology
MH  - Prednisolone/therapeutic use
MH  - Pyoderma Gangrenosum/drug therapy/*immunology/pathology
MH  - Vasculitis/drug therapy/*immunology/pathology
EDAT- 2002/10/29 04:00
MHDA- 2003/04/26 05:00
CRDT- 2002/10/29 04:00
PHST- 2002/10/29 04:00 [pubmed]
PHST- 2003/04/26 05:00 [medline]
PHST- 2002/10/29 04:00 [entrez]
AID - 10.1007/s00105-002-0385-1 [doi]
PST - ppublish
SO  - Hautarzt. 2002 Nov;53(11):730-4. doi: 10.1007/s00105-002-0385-1.