PMID- 12404203
OWN - NLM
STAT- MEDLINE
DCOM- 20021127
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 51
IP  - 11
DP  - 2002 Nov
TI  - Serum monocyte chemoattractant protein-1 is increased in chronic autoimmune 
      thyroiditis.
PG  - 1489-93
AB  - Chemokines are a large family of cytokines, which may be involved in the 
      pathogenesis of a wide variety of inflammatory or autoimmune conditions. The role 
      of chemokines in chronic autoimmune thyroiditis is unknown. We sought to examine 
      the role of CC chemokines in chronic autoimmune thyroiditis. We measured serum 
      levels of CC chemokines, including monocyte chemoattractant protein-1 (MCP-1) and 
      macrophage inflammatory protein 1a and 1b (MIP-1a and MIP-1b) in 32 women with 
      chronic autoimmune thyroiditis in comparison with 2 control groups (33 apparently 
      healthy women and 43 women with benign cold thyroid nodules) by enzyme-linked 
      immunosorbent assay (ELISA). We found a 45% increase in serum MCP-1 levels in 
      women with chronic autoimmune thyroiditis compared with either of the 2 control 
      groups (P =.01). There was no difference in either serum MIP-1a (P =.69) or 
      MIP-1b (P =.81) levels between women with chronic autoimmune thyroiditis and 
      controls. Among women with chronic autoimmune thyroiditis, women with a family 
      history of hypothyroidism had a 59% increase in serum MCP-1 levels compared with 
      women with no family history of hypothyroidism (P =.02). Serum MCP-1 levels were 
      associated with serum levels of antithyroid peroxidase (r =.2, P =.03) (anti-TPO 
      Ab) and antithyroglobulin (r =.2, P =.04) antibodies (anti-TG Ab). There was no 
      association between serum MCP-1 levels and serum free thyroxine index (P =.57), 
      triiodothyronine (T(3)) (P =.47) or thyroid-stimulating hormone (TSH) (P =.47) 
      levels. Serum MCP-1 is increased in women with chronic autoimmune thyroiditis, 
      especially in the presence of a family history of hypothyroidism, indicating a 
      possible pathogenetic role for MCP-1 in this condition.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Kokkotou, Efi
AU  - Kokkotou E
AD  - Joslin Diabetes Center, Boston, MA 02215, USA.
FAU - Marafelia, Panayota
AU  - Marafelia P
FAU - Mantzos, Emilia I
AU  - Mantzos EI
FAU - Tritos, Nicholas A
AU  - Tritos NA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokines)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL4
MH  - Chemokines/blood
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Macrophage Inflammatory Proteins/blood
MH  - Middle Aged
MH  - Thyroid Nodule/blood
MH  - Thyroiditis, Autoimmune/*blood
EDAT- 2002/10/31 04:00
MHDA- 2002/11/28 04:00
CRDT- 2002/10/31 04:00
PHST- 2002/10/31 04:00 [pubmed]
PHST- 2002/11/28 04:00 [medline]
PHST- 2002/10/31 04:00 [entrez]
AID - S0026049502001191 [pii]
AID - 10.1053/meta.2002.34717 [doi]
PST - ppublish
SO  - Metabolism. 2002 Nov;51(11):1489-93. doi: 10.1053/meta.2002.34717.