PMID- 12404687
OWN - NLM
STAT- MEDLINE
DCOM- 20030116
LR  - 20121115
IS  - 0885-6222 (Print)
IS  - 0885-6222 (Linking)
VI  - 17
IP  - 4
DP  - 2002 Jun
TI  - Effect of serotonin 1A agonist tandospirone on depression symptoms in senile 
      patients with dementia.
PG  - 191-3
AB  - The treatment of depression in senile patients with dementia is difficult with 
      the drugs used formerly. The effects of a new anxiolytic drug, tandospirone, were 
      investigated on depression symptoms in nine senile patients with dementia using 
      Hamilton Depression Rating Scale (HAM-D) items. Tandospirone improved the 
      symptoms, especially the depressive mood, agitation and anxiety, although a 
      slight gastrointestinal symptom was found in one patient. The findings in the 
      present study may suggest that tandospirone is a useful and comparatively safe 
      drug for depression symptoms in senile patients with dementia.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Masuda, Yutaka
AU  - Masuda Y
AD  - Psychosomatic Division, Akita University School of Medicine, 1-1-1 Hondo, Akita 
      010-8543, Japan.
FAU - Akagawa, Yusuke
AU  - Akagawa Y
FAU - Hishikawa, Yasuo
AU  - Hishikawa Y
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Isoindoles)
RN  - 0 (Piperazines)
RN  - 0 (Pyrimidines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Receptors, Serotonin, 5-HT1)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 190230I669 (tandospirone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/*drug therapy/*psychology
MH  - Depression/diagnosis/*drug therapy
MH  - Humans
MH  - Isoindoles
MH  - Piperazines/*therapeutic use
MH  - Psychiatric Status Rating Scales
MH  - Pyrimidines/*therapeutic use
MH  - Receptors, Serotonin/*metabolism
MH  - Receptors, Serotonin, 5-HT1
MH  - Serotonin Receptor Agonists/*therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2002/10/31 04:00
MHDA- 2003/01/17 04:00
CRDT- 2002/10/31 04:00
PHST- 2002/10/31 04:00 [pubmed]
PHST- 2003/01/17 04:00 [medline]
PHST- 2002/10/31 04:00 [entrez]
AID - 10.1002/hup.393 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2002 Jun;17(4):191-3. doi: 10.1002/hup.393.