PMID- 12406857
OWN - NLM
STAT- MEDLINE
DCOM- 20030108
LR  - 20121115
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 166
IP  - 10
DP  - 2002 Nov 15
TI  - Characterization of high-altitude pulmonary hypertension in the Kyrgyz: 
      association with angiotensin-converting enzyme genotype.
PG  - 1396-402
AB  - Previous studies have suggested a genetic component in susceptibility to 
      hypoxia-induced pulmonary hypertension. We therefore estimated the prevalence of 
      high-altitude pulmonary hypertension (HAPH) in a Kyrgyz population and whether 
      the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme 
      (ACE) gene associates with HAPH. An electrocardiographic survey of 741 
      highlanders demonstrated electrocardiogram signs of cor pulmonale in 14% of 
      subjects. Pulmonary artery hemodynamics measured in an independent group of 136 
      male highlanders with symptoms of dyspnea at altitude revealed established 
      pulmonary hypertension (mean pulmonary artery pressure [MPAP] > or = 25 mm Hg) in 
      20%. However, 26% of the normal subjects demonstrated an exaggerated response 
      (twofold or greater increase in MPAP) to inhalation of 11% oxygen, and were 
      classified as hyperresponsive. Ten-year follow-up of this group revealed 
      increases in the MPAP, but not in normal subjects. Comparison of ACE I/D 
      genotypes in the catheterized group revealed a threefold higher frequency of the 
      I/I genotype in highlanders with HAPH, compared with normal highlanders (chi2 = 
      11.59, p = 0.003). In addition, MPAP was higher in highlanders with the I/I 
      genotype (26.9 +/- 4.0 mm Hg) compared with the I/D genotype (20.6 +/- 1.2 mm Hg) 
      or the D/D genotype (18.3 +/- 0.9 mm Hg) (p < 0.05). We conclude that HAPH is 
      associated with ACE I/D genotype among Kyrgyz highlanders and the development of 
      HAPH in this population and may be predicted by hyperresponsiveness to acute 
      hypoxia.
FAU - Aldashev, Almaz A
AU  - Aldashev AA
AD  - National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan. 
      nwm23@cam.ac.uk
FAU - Sarybaev, Akpay S
AU  - Sarybaev AS
FAU - Sydykov, Akyl S
AU  - Sydykov AS
FAU - Kalmyrzaev, Bolot B
AU  - Kalmyrzaev BB
FAU - Kim, Elena V
AU  - Kim EV
FAU - Mamanova, Lira B
AU  - Mamanova LB
FAU - Maripov, Rashid
AU  - Maripov R
FAU - Kojonazarov, Baktybek K
AU  - Kojonazarov BK
FAU - Mirrakhimov, Mirsaid M
AU  - Mirrakhimov MM
FAU - Wilkins, Martin R
AU  - Wilkins MR
FAU - Morrell, Nicholas W
AU  - Morrell NW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020828
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Bacterial Outer Membrane Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Airway Resistance/physiology
MH  - Bacterial Outer Membrane Proteins/genetics/metabolism
MH  - Cardiac Catheterization
MH  - Electrocardiography
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Gene Frequency/genetics
MH  - Genetic Markers/physiology
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Hypertension, Pulmonary/blood/epidemiology/*genetics
MH  - Kyrgyzstan/epidemiology
MH  - Lung/blood supply/pathology
MH  - Male
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/genetics/metabolism
MH  - Polymorphism, Genetic/genetics
MH  - Prevalence
MH  - Pulmonary Heart Disease/blood/epidemiology/genetics
MH  - Pulmonary Wedge Pressure/physiology
MH  - Vital Capacity/physiology
EDAT- 2002/10/31 04:00
MHDA- 2003/01/09 04:00
CRDT- 2002/10/31 04:00
PHST- 2002/10/31 04:00 [pubmed]
PHST- 2003/01/09 04:00 [medline]
PHST- 2002/10/31 04:00 [entrez]
AID - 200204-345OC [pii]
AID - 10.1164/rccm.200204-345OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2002 Nov 15;166(10):1396-402. doi: 
      10.1164/rccm.200204-345OC. Epub 2002 Aug 28.