PMID- 12406887
OWN - NLM
STAT- MEDLINE
DCOM- 20030401
LR  - 20231213
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 101
IP  - 5
DP  - 2003 Mar 1
TI  - Simian immunodeficiency virus dramatically alters expression of homeostatic 
      chemokines and dendritic cell markers during infection in vivo.
PG  - 1684-91
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that likely play 
      multiple roles in human immunodeficiency virus type 1 (HIV-1) pathogenesis. We 
      used the simian immunodeficiency virus (SIV)/macaque model to study the effects 
      of infection on homeostatic chemokine expression and DC localization directly in 
      secondary lymphoid tissues. SIV infection altered the expression of chemokines 
      (CCL19/MIP-3beta, CCL21/ 6Ckine, and CCL20/MIP-3alpha) and of chemokine receptors 
      (CCR7 and CCR6) that drive DC trafficking. CCL19/MIP-3beta, CCL20/MIP-3alpha, 
      CCR6, and CCR7 expression increased in lymph nodes during the early systemic 
      burst of viral replication (acute infection), whereas CCL21/6Ckine expression 
      progressively decreased throughout disease to AIDS. Parallel with the SIV-induced 
      perturbations in chemokine expression were changes in the expression of the 
      DC-associated markers, DC-SIGN, DC-LAMP, and DECTIN-1. During AIDS, DC-LAMP mRNA 
      expression levels were significantly reduced in lymph nodes and spleen, and 
      DC-SIGN levels were significantly reduced in spleen. These findings suggest that 
      the disruption of homeostatic chemokine expression is responsible, in part, for 
      alterations in the networks of antigen-presenting cells in lymphoid tissues, 
      ultimately contributing to systemic immunodeficiency.
FAU - Choi, Yang Kyu
AU  - Choi YK
AD  - Department of Infectious Diseases and Microbiology and the Department of 
      Molecular Genetics and Biochemistry, University of Pittsburgh, PA.
FAU - Fallert, Beth A
AU  - Fallert BA
FAU - Murphey-Corb, Michael A
AU  - Murphey-Corb MA
FAU - Reinhart, Todd A
AU  - Reinhart TA
LA  - eng
GR  - HL62056/HL/NHLBI NIH HHS/United States
GR  - MH61205/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20021024
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD)
RN  - 0 (CCL19 protein, human)
RN  - 0 (CCL20 protein, human)
RN  - 0 (CCL21 protein, human)
RN  - 0 (CCR6 protein, human)
RN  - 0 (CCR7 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL19)
RN  - 0 (Chemokine CCL20)
RN  - 0 (Chemokine CCL21)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, CCR6)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (dectin 1)
SB  - IM
MH  - Animals
MH  - Antigens, CD/biosynthesis/genetics
MH  - Cell Adhesion Molecules/biosynthesis/genetics
MH  - Chemokine CCL19
MH  - Chemokine CCL20
MH  - Chemokine CCL21
MH  - Chemokines/*biosynthesis/genetics
MH  - Chemokines, CC/biosynthesis/genetics
MH  - Dendritic Cells/metabolism/*pathology
MH  - Disease Progression
MH  - *Gene Expression Regulation, Viral
MH  - Homeostasis
MH  - Lectins, C-Type/biosynthesis/genetics
MH  - Lymph Nodes/metabolism/pathology
MH  - Lysosomal Membrane Proteins
MH  - Macaca mulatta
MH  - Macrophage Inflammatory Proteins/biosynthesis/genetics
MH  - Membrane Proteins/biosynthesis/genetics
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - Receptors, CCR6
MH  - Receptors, CCR7
MH  - Receptors, Cell Surface/biosynthesis/genetics
MH  - Receptors, Chemokine/*biosynthesis/genetics
MH  - Simian Acquired Immunodeficiency Syndrome/immunology/*metabolism/pathology
MH  - Simian Immunodeficiency Virus/*physiology
MH  - Spleen/metabolism/pathology
MH  - Virus Replication
EDAT- 2002/10/31 04:00
MHDA- 2003/04/02 05:00
CRDT- 2002/10/31 04:00
PHST- 2002/10/31 04:00 [pubmed]
PHST- 2003/04/02 05:00 [medline]
PHST- 2002/10/31 04:00 [entrez]
AID - S0006-4971(20)50855-0 [pii]
AID - 10.1182/blood-2002-08-2653 [doi]
PST - ppublish
SO  - Blood. 2003 Mar 1;101(5):1684-91. doi: 10.1182/blood-2002-08-2653. Epub 2002 Oct 
      24.