PMID- 12408680
OWN - NLM
STAT- MEDLINE
DCOM- 20030508
LR  - 20191106
IS  - 1350-6129 (Print)
IS  - 1350-6129 (Linking)
VI  - 9
IP  - 3
DP  - 2002 Sep
TI  - Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in 
      hemodialysis patients.
PG  - 175-82
AB  - Carpal-tunnel syndrome (CTS) in long-term hemodialysis patients is caused by the 
      deposition of amyloid as well as by the local inflammatory process. The 
      recruitment of monocytes/macrophages in the tenosynovium, promoted by chemokines 
      such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory 
      protein-1alpha (MIP-1alpha), is thought to play an important role in CTS 
      development. The genetic polymorphism of these chemokines has been identified and 
      their clinical function has been partly revealed We attempted to analyze the 
      relationship between these polymorphisms and their susceptibility to CTS. The 
      subjects of this study were 366 patients who underwent hemodialysis. Ninety-five 
      patients received surgery for CTS. No significant difference was observed in the 
      genotype distributions of MCP-1 or MIP-1alpha between patients who received CTS 
      surgery and those that did not. However, with the use of a logistic regression 
      model, the MCP-1 GG genotype was identified as a risk factor for the development 
      of CTS, in addition to the duration and the age of initiation of dialysis, as 
      confirmed by a Cox proportional hazards model. In conclusion, homozygosity for G 
      at -2518 in the MCP-1 gene might be a candidate for the genetic marker of CTS 
      development in Japanese hemodialysis patients.
FAU - Omori, Kentaro
AU  - Omori K
AD  - Division of Clinical Nephrology and Rheumatology, Niigata University Graduate 
      School of Medical and Dental Sciences, Japan.
FAU - Kazama, Junichiro James
AU  - Kazama JJ
FAU - Song, Jin
AU  - Song J
FAU - Goto, Shin
AU  - Goto S
FAU - Takada, Toshinori
AU  - Takada T
FAU - Saito, Noriko
AU  - Saito N
FAU - Sakatsume, Minoru
AU  - Sakatsume M
FAU - Narita, Ichiei
AU  - Narita I
FAU - Gejyo, Fumitake
AU  - Gejyo F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Amyloid
JT  - Amyloid : the international journal of experimental and clinical investigation : 
      the official journal of the International Society of Amyloidosis
JID - 9433802
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Carpal Tunnel Syndrome/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Japan
MH  - Male
MH  - Microsatellite Repeats
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Renal Dialysis/*adverse effects
EDAT- 2002/11/01 04:00
MHDA- 2003/05/09 05:00
CRDT- 2002/11/01 04:00
PHST- 2002/11/01 04:00 [pubmed]
PHST- 2003/05/09 05:00 [medline]
PHST- 2002/11/01 04:00 [entrez]
AID - 10.3109/13506120209114819 [doi]
PST - ppublish
SO  - Amyloid. 2002 Sep;9(3):175-82. doi: 10.3109/13506120209114819.