PMID- 12409155
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20190916
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 58
IP  - 2-3
DP  - 2002 Dec 1
TI  - A functional anatomic study of emotion in schizophrenia.
PG  - 159-72
AB  - Using salient pictures with aversive (AV) and non-aversive (NA) content, we 
      probed limbic-emotional function in schizophrenia, testing specific hypotheses 
      that the amygdala would exhibit abnormal activity and a relationship with 
      positive symptoms. Fourteen schizophrenic patients and 13 healthy comparison 
      subjects viewed pictures during [15O] water positron emission tomography (PET). 
      Both groups reported identical subjective experience of the aversive stimuli and 
      both activated right insula (AV-NA). The schizophrenic group showed greater 
      activation of the medial prefrontal cortex (MPFC) for the AV-NA comparison. 
      Control subjects activated bilateral amygdaloid and orbitofrontal regions for NA 
      relative to a blank condition (simple visual fixation, BL), whereas schizophrenic 
      subjects only activated left orbitofrontal cortex. Activity in the left amygdala 
      correlated with positive symptoms in the patients. Both groups activated visual 
      cortex, and the schizophrenic subjects exhibited less modulation throughout 
      visual cortex for NA-BL, as well as more focused deficits in the left fusiform 
      and left mid-occipital gyrus for AV-NA, possibly related to decreased eye 
      movements in the schizophrenic patients. Overall, the data are consistent with a 
      general failure to process salient stimuli in schizophrenia, and the findings 
      support the involvement of the amygdala in the positive symptoms of 
      schizophrenia.
FAU - Taylor, Stephan F
AU  - Taylor SF
AD  - Department of Psychiatry, University of Michigan Medical Center, UH 9D Box 0118, 
      1500 E. Medical Center Drive, Ann Arbor MI 48109-0118, USA. sftaylor@umich.edu
FAU - Liberzon, Israel
AU  - Liberzon I
FAU - Decker, Laura R
AU  - Decker LR
FAU - Koeppe, Robert A
AU  - Koeppe RA
LA  - eng
GR  - K08 MH01258/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Amygdala/metabolism/physiopathology
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain/*metabolism/physiopathology
MH  - Eye Movements/physiology
MH  - Female
MH  - Galvanic Skin Response/physiology
MH  - Humans
MH  - Male
MH  - Mood Disorders/diagnosis/*etiology
MH  - Occipital Lobe/metabolism/physiopathology
MH  - Prefrontal Cortex/metabolism/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - *Schizophrenia/drug therapy/*metabolism/physiopathology
MH  - Severity of Illness Index
MH  - Tomography, Emission-Computed
MH  - Visual Cortex/metabolism/physiopathology
EDAT- 2002/11/01 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/11/01 04:00
PHST- 2002/11/01 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/11/01 04:00 [entrez]
AID - S0920996401004030 [pii]
AID - 10.1016/s0920-9964(01)00403-0 [doi]
PST - ppublish
SO  - Schizophr Res. 2002 Dec 1;58(2-3):159-72. doi: 10.1016/s0920-9964(01)00403-0.