PMID- 12409215
OWN - NLM
STAT- MEDLINE
DCOM- 20030624
LR  - 20190901
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 109
IP  - 1-3
DP  - 2002 Nov 15
TI  - The effects of pituitary adenylate cyclase-activating polypeptide on acute and 
      chronic morphine actions in mice.
PG  - 57-62
AB  - The effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on pain 
      sensitivity, on morphine analgesia, on morphine tolerance and withdrawal were 
      investigated in mice. The heat-radiant tail-flick test was used to assess 
      antinociceptive threshold. Intracerebroventricular (i.c.v.) administration of 
      PACAP alone had no effect on pain sensitivity but in a dose of 500 ng, it 
      significantly diminished the analgesic effect of a single dose of morphine (2.25 
      mg/kg, s.c.). PACAP (500 ng, i.c.v.) significantly increased the chronic 
      tolerance to morphine and enhanced the naloxone (1 mg/kg, s.c.)-precipitated 
      withdrawal jumping. Theophylline (1 mg/kg, i.p.) pretreatment significantly 
      enhanced the effect of PACAP on morphine analgesia but the effects of PACAP on 
      tolerance and withdrawal were unaffected upon theophylline administration. On the 
      grounds of our previous studies with vasoactive intestinal polypeptide (VIP), it 
      appears that different receptors are involved in the effects of PACAP in acute 
      and chronic morphine actions. Our results indicate that PACAP-induced actions 
      likely participate in acute and chronic effects of morphine and suggest a 
      potential role of PACAP in opioid analgesia, tolerance and withdrawal.
FAU - Macsai, Monika
AU  - Macsai M
AD  - Department of Pathophysiology, Albert Szent-Gyorgyi Medical and Pharmaceutical 
      Center, University of Szeged, Hungary.
FAU - Pataki, Imre
AU  - Pataki I
FAU - Toth, Gabor
AU  - Toth G
FAU - Szabo, Gyula
AU  - Szabo G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Adcyap1 protein, mouse)
RN  - 0 (Analgesics)
RN  - 0 (Neuropeptides)
RN  - 0 (Pituitary Adenylate Cyclase-Activating Polypeptide)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Drug Synergism
MH  - Drug Tolerance
MH  - Male
MH  - Mice
MH  - Morphine/*pharmacology
MH  - Neuropeptides/administration & dosage/*pharmacology
MH  - Pain Threshold/*drug effects
MH  - Pituitary Adenylate Cyclase-Activating Polypeptide
MH  - Substance Withdrawal Syndrome
MH  - Time Factors
EDAT- 2002/11/01 04:00
MHDA- 2003/06/25 05:00
CRDT- 2002/11/01 04:00
PHST- 2002/11/01 04:00 [pubmed]
PHST- 2003/06/25 05:00 [medline]
PHST- 2002/11/01 04:00 [entrez]
AID - S0167011502001878 [pii]
AID - 10.1016/s0167-0115(02)00187-8 [doi]
PST - ppublish
SO  - Regul Pept. 2002 Nov 15;109(1-3):57-62. doi: 10.1016/s0167-0115(02)00187-8.