PMID- 12412424
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20140625
VI  - 16
IP  - 8
DP  - 2002 Aug
TI  - [The expression of transforming growth factor alpha, beta 1 in hyperplastic 
      tissue after endoscopic polypectomy and the effect of corticosteroid].
PG  - 399-401
AB  - OBJECTIVE: To study the expression of transforming growth factor alpha, beta 1 in 
      hyperplastic tissue after endoscopic polypectomy and the effect of 
      corticosteroid. METHOD: Forty patients with nasal polyps were divided into two 
      groups randomly: corticosteroid group (n = 20) with topical application of 
      Budesonide (BUD, 400 micrograms/d) after endoscopic polypectomy and control group 
      (n = 20) without corticosteroid after surgery. The hyperplastic tissues in 
      operative cavity obtained in the 1st and 8th weeks after operation were studied 
      with HE staining and immunohistochemistry technique respectively. RESULT: 
      Morphological changes of hyperplastic tissue after endoscopic polypectomy 
      included pseudostratified epithelium, highly edematous lamina proper and 
      inflammatory cells infiltration, in which the main infiltrative cells were 
      eosinophils (67.5%). Transforming growth factor alpha(TGF alpha) protein was 
      highly expressed in epithelial cells, grand cells and inflammatory cells in the 
      hyperplastic tissue. Transforming growth factor beta 1 (TGF beta 1) protein was 
      highly expressed in inflammatory cells in the hyperplastic tissue. The expression 
      of TGF alpha and beta 1 was significantly decreased after topical BUD spray (P < 
      0.01, 0.05). CONCLUSION: Transforming growth factor alpha and beta 1 may play an 
      important role in the formation and recurrence of nasal polyps.
FAU - Chen, Fuquan
AU  - Chen F
AD  - Department of Otolaryngology, Xijing Hospital, Fourth Military Medical 
      University, Xi'an 710032.
FAU - Huang, Weiguo
AU  - Huang W
FAU - Qiao, Li
AU  - Qiao L
FAU - Jiang, Hongyan
AU  - Jiang H
FAU - Qiu, Jianhua
AU  - Qiu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 0 (Transforming Growth Factor beta)
RN  - 51333-22-3 (Budesonide)
SB  - IM
MH  - Adult
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Budesonide/*pharmacology
MH  - Female
MH  - Humans
MH  - Hyperplasia/metabolism
MH  - Male
MH  - Nasal Mucosa/*pathology
MH  - Nasal Polyps/*metabolism/pathology/surgery
MH  - Transforming Growth Factor alpha/*biosynthesis/drug effects
MH  - Transforming Growth Factor beta/*biosynthesis/drug effects
EDAT- 2002/11/05 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/11/05 04:00
PHST- 2002/11/05 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/11/05 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Aug;16(8):399-401.