PMID- 12412788
OWN - NLM
STAT- MEDLINE
DCOM- 20030513
LR  - 20071114
IS  - 0884-0431 (Print)
IS  - 0884-0431 (Linking)
VI  - 17 Suppl 2
DP  - 2002 Nov
TI  - Non-classical target organs in primary hyperparathyroidism.
PG  - N117-25
AB  - Classical primary hyperparathyroidism (PHPT) was a multisystem disorder with 
      clear neurologic, psychiatric, gastrointestinal, and cardiovascular consequences. 
      The nature and extent of involvement of these target organs in the modern 
      presentation of the disease are controversial. Although hypertension has been 
      associated with PHPT, it is not cured after parathyroidectomy, nor is it easier 
      to control. Despite significant data on European patients, information on the 
      incidence of cardiovascular abnormalities in American patients with mild disease 
      are limited. Investigation is turning to more subtle abnormalities, such as 
      vascular reactivity and endothelial function, where data are conflicting. Many 
      patients complain of nonspecific neuropsychiatric symptoms. This has been a 
      difficult area to study quantitatively. Classical neuromuscular disease is rare 
      in mild PHPT, although weakness and easy fatigability remain common complaints. 
      These nonspecific symptoms may or may not improve with surgery. While no clear 
      causal association exists between sporadic PHPT and peptic ulcer disease, this is 
      not the case in patients with multiple endocrine neoplasia type 1 (MEN1). 
      Gastrinoma is more severe in those with coexisting PHPT, and Zollinger-Ellison 
      Syndrome improves with treatment of PHPT. Further efforts are necessary to 
      characterize the cardiovascular and neuropsychological profiles of mild PHPT and 
      to determine the longitudinal course of such alterations. With available data 
      suggesting that many asymptomatic patients with PHPT can be safely followed 
      without parathyroidectomy, this information will be of key importance in the 
      management of such individuals.
FAU - Silverberg, Shonni J
AU  - Silverberg SJ
AD  - Department of Medicine, College of Physicians and Surgeons, Columbia University, 
      New York, New York 10032, USA.
LA  - eng
GR  - NIDDK 32333/DK/NIDDK NIH HHS/United States
GR  - RR 00645/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
SB  - IM
MH  - Behavioral Symptoms/*etiology/psychology
MH  - Cardiovascular Diseases/*etiology
MH  - Gastrointestinal Diseases/*etiology
MH  - Humans
MH  - Hyperparathyroidism/*complications/physiopathology
MH  - Nervous System Diseases/*etiology/psychology
RF  - 73
EDAT- 2002/11/05 04:00
MHDA- 2003/05/14 05:00
CRDT- 2002/11/05 04:00
PHST- 2002/11/05 04:00 [pubmed]
PHST- 2003/05/14 05:00 [medline]
PHST- 2002/11/05 04:00 [entrez]
PST - ppublish
SO  - J Bone Miner Res. 2002 Nov;17 Suppl 2:N117-25.