PMID- 12413731
OWN - NLM
STAT- MEDLINE
DCOM- 20030508
LR  - 20190826
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 84
IP  - 3
DP  - 2002 Dec 3
TI  - Human regional lymph nodes draining cancer exhibit a profound dendritic cell 
      depletion as comparing to those from patients without malignancies.
PG  - 159-62
AB  - Dendritic cells (DCs) are bone-marrow derived 'professional' antigen presenting 
      cells (APC). They are considered as the most potent APC able to induce primary 
      immune responses. DC efficiently capture and process proteic and non-proteic 
      antigens. They are widely distributed throughout the body and occupy sentinel 
      positions such as epithelia. Establishment of an immune response against cancer 
      may depend of the capacity of DCs to transfer (to capture, to process and to 
      present) tumor antigens into regional lymph nodes where they can induce a 
      specific response leading to tumor rejection. Because host 'professional' DCs are 
      one of the most important elements in the induction of specific anti-tumor 
      responses and lymph nodes are the places where the immune response takes place, 
      we investigated the densities of DCs within regional metastasis-free lymph nodes 
      from 47 patients with different malignant epithelial tumors as comparing with 
      lymph nodes from 11 patients without malignancies using an immunohistochemistry 
      method with anti-S100 protein, CD86 and CD1a antibodies. By means of morphometric 
      analysis, we observed that S100+ and CD1a+ DCs densities in regional lymph nodes 
      from cancer patients were significatively decreased as compared with control 
      lymph nodes (P<0.0001 and 0.003, respectively). S100+ DCs and CD86+ DCs densities 
      in lymph nodes draining cancer were similar. Taken together, these data indicated 
      that lymph nodes draining cancer had significantly less CD1a+ DCs than S100+ and 
      possibly CD86+ DCs. These findings may represent another mechanism by which 
      tumors evade the immune recognition.
FAU - Laguens, Graciela
AU  - Laguens G
AD  - Departamento de Patologia, Facultad de Ciencias Medicas, Universidad Nacional de 
      La Plata, 65 No. 309 (1 y 2), La Plata 1900, Argentina. glaguens@infovia.com.ar
FAU - Coronato, Silvia
AU  - Coronato S
FAU - Laguens, Ruben
AU  - Laguens R
FAU - Portiansky, Enrique
AU  - Portiansky E
FAU - Di Girolamo, Vanda
AU  - Di Girolamo V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (B7-2 Antigen)
RN  - 0 (CD1a antigen)
RN  - 0 (CD86 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - Antigens, CD1/metabolism
MH  - B7-2 Antigen
MH  - Cell Count
MH  - Dendritic Cells/*immunology/metabolism/pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Lymph Nodes/*immunology/metabolism/pathology
MH  - Membrane Glycoproteins/metabolism
MH  - Neoplasms, Glandular and Epithelial/*immunology/metabolism/pathology
MH  - S100 Proteins/metabolism
EDAT- 2002/11/05 04:00
MHDA- 2003/05/09 05:00
CRDT- 2002/11/05 04:00
PHST- 2002/11/05 04:00 [pubmed]
PHST- 2003/05/09 05:00 [medline]
PHST- 2002/11/05 04:00 [entrez]
AID - S0165247802001724 [pii]
AID - 10.1016/s0165-2478(02)00172-4 [doi]
PST - ppublish
SO  - Immunol Lett. 2002 Dec 3;84(3):159-62. doi: 10.1016/s0165-2478(02)00172-4.