PMID- 12413765
OWN - NLM
STAT- MEDLINE
DCOM- 20030520
LR  - 20221207
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 30
IP  - 2
DP  - 2002 Nov
TI  - Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in 
      Japanese patients.
PG  - 100-7
AB  - Interleukin (IL)-13 plays an important role in the induction of immunoglobulin E 
      (IgE) and in the pathogenesis of atopic dermatitis (AD). We investigated the 
      allele and genotype frequencies of three IL-13 single nucleotide polymorphisms 
      (SNPs) (A704C and C1103T in the promoter region and G4257A in exon 4) in Japanese 
      patients with AD. For A704C and C1103T SNPs, there were no significant 
      differences in allele or genotype frequencies between AD patients and controls. 
      For G4257A SNP, A allele was significantly increased in AD patients (39.5%) 
      compared with controls (29.4%) (P = 0.016). The same proportion of each genotype 
      and allele was observed in the patient subgroup with and without asthma. Serum 
      IgE levels and peripheral eosinophil counts were not significantly different 
      among genotypes in G4257A SNP. There was also no significant difference in allele 
      or genotype frequencies between AD patients with mild disease and those with 
      severe disease, between those with family history of AD and those without it, or 
      between those with family history of atopic disorders and those without it. This 
      result suggests that 4257A allele is associated with susceptibility to AD and 
      that it may function in the pathogenesis of AD itself, presumably by other 
      mechanisms than inducing IgE production.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Tsunemi, Yuichiro
AU  - Tsunemi Y
AD  - Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo 113-8655, Japan. ytsun-tky@umin.ac.jp
FAU - Saeki, Hidehisa
AU  - Saeki H
FAU - Nakamura, Koichiro
AU  - Nakamura K
FAU - Sekiya, Takashi
AU  - Sekiya T
FAU - Hirai, Koichi
AU  - Hirai K
FAU - Kakinuma, Takashi
AU  - Kakinuma T
FAU - Fujita, Hideki
AU  - Fujita H
FAU - Asano, Noriko
AU  - Asano N
FAU - Tanida, Yuka
AU  - Tanida Y
FAU - Wakugawa, Motoshi
AU  - Wakugawa M
FAU - Torii, Hideshi
AU  - Torii H
FAU - Tamaki, Kunihiko
AU  - Tamaki K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Interleukin-13)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics
MH  - Child
MH  - Dermatitis, Atopic/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Interleukin-13/*genetics
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2002/11/05 04:00
MHDA- 2003/05/21 05:00
CRDT- 2002/11/05 04:00
PHST- 2002/11/05 04:00 [pubmed]
PHST- 2003/05/21 05:00 [medline]
PHST- 2002/11/05 04:00 [entrez]
AID - S0923181102000658 [pii]
AID - 10.1016/s0923-1811(02)00065-8 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2002 Nov;30(2):100-7. doi: 10.1016/s0923-1811(02)00065-8.