PMID- 12416023
OWN - NLM
STAT- MEDLINE
DCOM- 20030606
LR  - 20220409
IS  - 1359-4117 (Print)
IS  - 1359-4117 (Linking)
VI  - 2
IP  - 4
DP  - 2002 Jul-Aug
TI  - Inhibitory effect of vitamin D3 on 3'methyl-4-dimethyl-amino-azobenzene-induced 
      rat hepatocarcinogenesis: a study on antioxidant defense enzymes.
PG  - 193-9
AB  - The anticarcinogenic effect of vitamin D3 (VD3) on 
      3,-methyl-4-dimethyl-amino-azobenzene (3,-Met-DAB)-induced hepatocarcinogenesis 
      was investigated in male Sprague-Dawley rats. Anticancer efficacy of VD3 was 
      estimated using different possible biomarkers, namely reduced glutathione (GSH) 
      concentration, gamma-glutamyl transpeptidase (GGT) activity, glutathione 
      S-transferase (GST) activity, glutathione reductase (GRd) activity, glutathione 
      peroxidase (GPx) activity in hyperplastic nodules (HNs) and non-nodular 
      surrounding parenchyma (NNSP) liver areas. VD3 was found to control the 
      carcinogen-induced alterations in GSH level, GST, GGT, GRd and GPx activity both 
      in HNs and NNSP liver areas during long-term exposure. A decrease in the number 
      of HNs was also evident in the present investigation. VD3 was proved to be an 
      effective antitumor drug during the initiation/promotion phases of hepatic 
      carcinogenesis but the effect was found to be less prominent during initiation 
      and promotion phases.
FAU - Karmakar, Ranajit
AU  - Karmakar R
AD  - Department of Zoology, Taki Government College, Taki, North 24 Parganas, West 
      Bengal, India. rk_wbes@lycos.com
FAU - Banik, Sarmistha
AU  - Banik S
FAU - Chatterjee, Malay
AU  - Chatterjee M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Ther Oncol
JT  - Journal of experimental therapeutics & oncology
JID - 9604933
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Antioxidants)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 57X2AH42T1 (p-Aminoazobenzene)
RN  - 64-01-7 (3-methyl-4-methylaminoazobenzene)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Antioxidants/*metabolism
MH  - Carcinoma, Hepatocellular/*chemically induced/*enzymology/metabolism/pathology
MH  - Cell Division/drug effects
MH  - Cholecalciferol/*pharmacology
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - gamma-Glutamyltransferase/metabolism
MH  - p-Aminoazobenzene/*analogs & derivatives/*pharmacology
EDAT- 2002/11/06 04:00
MHDA- 2003/06/07 05:00
CRDT- 2002/11/06 04:00
PHST- 2002/11/06 04:00 [pubmed]
PHST- 2003/06/07 05:00 [medline]
PHST- 2002/11/06 04:00 [entrez]
AID - 10.1046/j.1359-4117.2002.01032.x [doi]
PST - ppublish
SO  - J Exp Ther Oncol. 2002 Jul-Aug;2(4):193-9. doi: 10.1046/j.1359-4117.2002.01032.x.