PMID- 12417648
OWN - NLM
STAT- MEDLINE
DCOM- 20021125
LR  - 20220408
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 22
IP  - 21
DP  - 2002 Nov 1
TI  - Microglia-Muller glia cell interactions control neurotrophic factor production 
      during light-induced retinal degeneration.
PG  - 9228-36
AB  - Activation of microglia commonly occurs in response to a wide variety of 
      pathological stimuli including trauma, axotomy, ischemia, and degeneration in the 
      CNS. In the retina, prolonged or high-intensity exposure to visible light leads 
      to photoreceptor cell apoptosis. In such a light-reared retina, we found that 
      activated microglia invade the degenerating photoreceptor layer and alter 
      expression of neurotrophic factors such as nerve growth factor (NGF), ciliary 
      neurotrophic factor (CNTF), and glial cell line-derived neurotrophic factor 
      (GDNF). Because these neurotrophic factors modulate secondary trophic factor 
      expression in Muller glial cells, microglia-Muller glia cell interaction may 
      contribute to protection of photoreceptors or increase photoreceptor apoptosis. 
      In the present study, we demonstrate the possibility that such functional 
      glia-glia interactions constitute the key mechanism by which microglia-derived 
      NGF, brain-derived neurotrophic factor (BDNF), and CNTF indirectly influence 
      photoreceptor survival, although the receptors for these neurotrophic factors are 
      absent from photoreceptors, by modulating basic fibroblast growth factor (bFGF) 
      and GDNF production and release from Muller glia. These observations suggest that 
      microglia regulate the microglia-Muller glia-photoreceptor network that serves as 
      a trophic factor-controlling system during retinal degeneration.
FAU - Harada, Takayuki
AU  - Harada T
AD  - Department of Degenerative Neurological Diseases, National Institute of 
      Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 
      187-8502, Japan.harada.aud@mri.tmd.ac.jp
FAU - Harada, Chikako
AU  - Harada C
FAU - Kohsaka, Shinichi
AU  - Kohsaka S
FAU - Wada, Etsuko
AU  - Wada E
FAU - Yoshida, Kazuhiko
AU  - Yoshida K
FAU - Ohno, Shigeaki
AU  - Ohno S
FAU - Mamada, Hiroshi
AU  - Mamada H
FAU - Tanaka, Kohichi
AU  - Tanaka K
FAU - Parada, Luis F
AU  - Parada LF
FAU - Wada, Keiji
AU  - Wada K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Gdnf protein, mouse)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Cell Movement/radiation effects
MH  - Cells, Cultured
MH  - Ciliary Neurotrophic Factor/biosynthesis/genetics
MH  - Disease Models, Animal
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Light/*adverse effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microglia/metabolism/pathology/radiation effects
MH  - Nerve Growth Factor/biosynthesis/genetics
MH  - Nerve Growth Factors/*biosynthesis/genetics
MH  - Neuroglia/*metabolism/pathology/*radiation effects
MH  - Neurotrophin 3/biosynthesis
MH  - Photoreceptor Cells/pathology/radiation effects
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Nerve Growth Factor
MH  - Receptors, Nerve Growth Factor/deficiency/genetics/metabolism
MH  - Retina/pathology/radiation effects
MH  - Retinal Degeneration/*metabolism/pathology
PMC - PMC6758038
EDAT- 2002/11/06 04:00
MHDA- 2002/11/26 04:00
PMCR- 2003/05/01
CRDT- 2002/11/06 04:00
PHST- 2002/11/06 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/11/06 04:00 [entrez]
PHST- 2003/05/01 00:00 [pmc-release]
AID - 22/21/9228 [pii]
AID - 6933 [pii]
AID - 10.1523/JNEUROSCI.22-21-09228.2002 [doi]
PST - ppublish
SO  - J Neurosci. 2002 Nov 1;22(21):9228-36. doi: 10.1523/JNEUROSCI.22-21-09228.2002.