PMID- 12419508
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20190822
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 40
IP  - 11
DP  - 2002 Nov
TI  - Local inflammatory reaction induced by Bothrops jararaca venom differs in mice 
      selected for acute inflammatory response.
PG  - 1571-9
AB  - Bothrops jararaca venom (BjV) causes severe systemic and local reactions, 
      characterized by an acute inflammatory reaction with accumulation of leukocytes 
      and release of endogenous mediators. The systemic and local effects of BjV were 
      compared in lines of mice genetically selected for maximal (AIR(max)) or minimal 
      (AIR(min)) acute inflammatory reactivity (AIR). The systemic reaction was 
      evaluated by LD(50) and the local reaction by edema formation, cellular influx, 
      release of PGE(2), NO and H(2)O(2) and the production of the pro-inflammatory 
      cytokines IL-6, Tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma. Both mouse 
      lines were equally susceptible to the lethal effects of the venom showing similar 
      LD(50) but differed significantly in terms of the local inflammatory reaction. 
      Footpad edema and leukocyte influx in the peritoneum after BjV inoculation was 
      higher in AIR(max) compared to AIR(min), BALB/c or outbred Swiss mice. 
      Coincidently, higher levels of the soluble mediators PGE(2), IFN-gamma and 
      TNF-alpha were detected in the inflammatory exudate induced by BjV in AIR(max) 
      mice. Cytokines levels were correlated to in vitro NO and H(2)O(2) production. 
      The results demonstrate that the genetic factors selected in AIR(max) and 
      AIR(min) lines of mice interfere in the control of the acute local reaction 
      triggered by BjV venom.
CI  - Copyright 2002 Elsevier Science Ltd.
FAU - Carneiro, Adriana S
AU  - Carneiro AS
AD  - Laboratorio de Imunogenetica, Instituto Butantan, Av Vital Brasil 1500-cep 
      05503-900 Sao Paulo, SP, Brazil.
FAU - Ribeiro, Orlando G
AU  - Ribeiro OG
FAU - De Franco, Marcelo
AU  - De Franco M
FAU - Cabrera, Wafa H K
AU  - Cabrera WH
FAU - Vorraro, Francisca
AU  - Vorraro F
FAU - Siqueira, Maria
AU  - Siqueira M
FAU - Ibanez, Olga M
AU  - Ibanez OM
FAU - Starobinas, Nancy
AU  - Starobinas N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Crotalid Venoms)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 82115-62-6 (Interferon-gamma)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - *Bothrops
MH  - Crotalid Venoms/administration & dosage/*toxicity
MH  - Cytokines/drug effects
MH  - Dinoprostone/metabolism
MH  - Edema/chemically induced/pathology
MH  - Female
MH  - Hydrogen Peroxide/metabolism
MH  - Inflammation/*chemically induced/pathology
MH  - Injections, Intraperitoneal
MH  - Interferon-gamma/drug effects
MH  - Interleukin-6/metabolism
MH  - Lethal Dose 50
MH  - Leukocytes/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred Strains
MH  - Nitric Oxide/metabolism
MH  - Tumor Necrosis Factor-alpha/drug effects
EDAT- 2002/11/07 04:00
MHDA- 2003/03/28 05:00
CRDT- 2002/11/07 04:00
PHST- 2002/11/07 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2002/11/07 04:00 [entrez]
AID - S0041010102001745 [pii]
AID - 10.1016/s0041-0101(02)00174-5 [doi]
PST - ppublish
SO  - Toxicon. 2002 Nov;40(11):1571-9. doi: 10.1016/s0041-0101(02)00174-5.