PMID- 12419786
OWN - NLM
STAT- MEDLINE
DCOM- 20021204
LR  - 20190513
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 94
IP  - 21
DP  - 2002 Nov 6
TI  - Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of 
      invasive cervical cancer.
PG  - 1604-13
AB  - BACKGROUND: Human papillomavirus (HPV) infection is the main cause of invasive 
      cervical cancer, but cofactors may act in conjunction with HPV. We performed a 
      pooled analysis of seven case-control studies to examine the effect of one 
      possible HPV cofactor, herpes simplex virus-2 (HSV-2) infection, in the etiology 
      of invasive cervical cancer. METHODS: Blood and exfoliated cervical specimens 
      were obtained from 1263 case patients with invasive cervical cancer (1158 with 
      squamous-cell carcinomas and 105 with adeno- or adenosquamous-cell carcinomas) 
      and 1117 age-matched control subjects. Western blot analysis and/or an 
      enzyme-linked immunosorbent assay were used to detect type-specific serum 
      antibodies to HSV-2 and HSV-1, and Chlamydia trachomatis serum antibodies were 
      detected using a micro-immunofluorescence assay. HPV DNA was detected using a 
      polymerase chain reaction assay. Summary odds ratios (ORs) and 95% confidence 
      intervals (CIs) were computed from unconditional logistic regression models. 
      RESULTS: Overall, HSV-2 seropositivity was higher among case patients with 
      squamous-cell carcinoma (44.4%, 95% CI = 41.5% to 47.3%) or adeno- or 
      adenosquamous-cell carcinoma (43.8%, 95% CI = 34.2% to 53.5%) than among control 
      subjects (25.6%, 95% CI = 23.0% to 28.2%). Cervical specimens from 1098 (94.8%) 
      squamous-cell carcinoma case patients, 95 (90.5%) adeno- or adenosquamous 
      carcinoma case patients, and 164 (14.7%) control subjects were positive for HPV 
      DNA. Among the HPV DNA-positive women, HSV-2 seropositivity was associated with 
      increased risks of squamous-cell carcinoma (OR = 2.19, 95% CI = 1.41 to 3.40) and 
      adeno- or adenosquamous-cell carcinoma (OR = 3.37, 95% CI = 1.47 to 7.74) after 
      adjustment for potential confounders. A similar association between HSV-2 
      seropositivity and squamous-cell carcinoma risk was observed after further 
      controlling for markers of sexual behavior (OR = 1.96, 95% CI = 1.24 to 3.09). 
      Among control subjects, HSV-2 seropositivity was associated with markers of 
      sexual behavior, but not with cervical HPV DNA positivity. CONCLUSION: HSV-2 
      infection may act in conjunction with HPV infection to increase the risk of 
      invasive cervical carcinoma.
FAU - Smith, Jennifer S
AU  - Smith JS
AD  - Unit of Field and Intervention Studies, International Agency for Research on 
      Cancer (IARC), Lyon, France. smith@iarc.fr
FAU - Herrero, Rolando
AU  - Herrero R
FAU - Bosetti, Cristina
AU  - Bosetti C
FAU - Munoz, Nubia
AU  - Munoz N
FAU - Bosch, F Xavier
AU  - Bosch FX
FAU - Eluf-Neto, Jose
AU  - Eluf-Neto J
FAU - Castellsague, Xavier
AU  - Castellsague X
FAU - Meijer, Chris J L M
AU  - Meijer CJ
FAU - Van den Brule, Adriaan J C
AU  - Van den Brule AJ
FAU - Franceschi, Silvia
AU  - Franceschi S
FAU - Ashley, Rhoda
AU  - Ashley R
CN  - International Agency for Research on Cancer (IARC) Multicentric Cervical Cancer 
      Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
CIN - J Natl Cancer Inst. 2002 Nov 6;94(21):1592-3. PMID: 12419778
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/blood
MH  - Coitus
MH  - DNA, Viral/genetics/isolation & purification
MH  - Female
MH  - Herpes Genitalis/complications/*virology
MH  - Herpesvirus 2, Human/isolation & purification/*pathogenicity
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Marriage
MH  - Middle Aged
MH  - Papillomaviridae/isolation & purification/pathogenicity
MH  - Papillomavirus Infections/complications/virology
MH  - Risk Factors
MH  - Sexual Behavior
MH  - Socioeconomic Factors
MH  - Uterine Cervical Neoplasms/epidemiology/*virology
EDAT- 2002/11/07 04:00
MHDA- 2002/12/05 04:00
CRDT- 2002/11/07 04:00
PHST- 2002/11/07 04:00 [pubmed]
PHST- 2002/12/05 04:00 [medline]
PHST- 2002/11/07 04:00 [entrez]
AID - 10.1093/jnci/94.21.1604 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2002 Nov 6;94(21):1604-13. doi: 10.1093/jnci/94.21.1604.