PMID- 12421338
OWN - NLM
STAT- MEDLINE
DCOM- 20030103
LR  - 20220129
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 14
IP  - 11
DP  - 2002 Nov
TI  - Centrally administered galanin-like peptide modifies food intake in the rat: a 
      comparison with galanin.
PG  - 853-60
AB  - Galanin-like peptide (GALP) is a recently identified neuropeptide that shares 
      sequence homology with the orexigenic neuropeptide, galanin. In contrast to 
      galanin, GALP is reported to bind preferentially to the galanin receptor 2 
      subtype (GalR2) compared to GalR1. The aim of this study was to determine the 
      effect of GALP on feeding, body weight and core body temperature after central 
      administration in rats compared to the effects of galanin. 
      Intracerebroventricular (i.c.v.) injection of GALP (1 micro g-10 micro g) 
      significantly stimulated feeding at 1 h in both satiated and fasted 
      Sprague-Dawley rats. However, 24 h after GALP injection, body weight gain was 
      significantly reduced and food intake was also usually decreased. In addition, 
      i.c.v. GALP caused a dose-related increase in core body temperature, which lasted 
      until 6-8 h after injection, and was reduced by peripheral administration of the 
      cyclooxygenase inhibitor, flurbiprofen (1 mg/kg). Similar to GALP, i.c.v. 
      injection of galanin (5 micro g) significantly increased feeding at 1 h in 
      satiated rats. However, there was no difference in food intake and body weight at 
      24 h, and galanin only caused a transient rise in body temperature. Thus, similar 
      to galanin, GALP has an acute orexigenic effect on feeding. However, GALP also 
      has an anorectic action, which is apparent at a later time. Therefore, GALP has 
      complex opposing actions on energy homeostasis.
FAU - Lawrence, C B
AU  - Lawrence CB
AD  - School of Biological Sciences, University of Manchester, UK.
FAU - Baudoin, F M-H
AU  - Baudoin FM
FAU - Luckman, S M
AU  - Luckman SM
LA  - eng
GR  - NEU15392/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Galanin-Like Peptide)
RN  - 0 (Nerve Tissue Proteins)
RN  - 5GRO578KLP (Flurbiprofen)
RN  - 88813-36-9 (Galanin)
SB  - IM
MH  - Animals
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Eating/*drug effects
MH  - Fasting/physiology
MH  - Flurbiprofen/pharmacology
MH  - Galanin/administration & dosage/pharmacology
MH  - Galanin-Like Peptide
MH  - Injections, Intraventricular
MH  - Male
MH  - Nerve Tissue Proteins/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Satiation/physiology
EDAT- 2002/11/08 04:00
MHDA- 2003/01/07 04:00
CRDT- 2002/11/08 04:00
PHST- 2002/11/08 04:00 [pubmed]
PHST- 2003/01/07 04:00 [medline]
PHST- 2002/11/08 04:00 [entrez]
AID - 846 [pii]
AID - 10.1046/j.1365-2826.2002.00846.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2002 Nov;14(11):853-60. doi: 10.1046/j.1365-2826.2002.00846.x.