PMID- 12423025
OWN - NLM
STAT- MEDLINE
DCOM- 20030225
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 14
IP  - 6
DP  - 2002 Nov
TI  - Case-control study on the association of porcine circovirus type 2 and other 
      swine viral pathogens with postweaning multisystemic wasting syndrome.
PG  - 449-56
AB  - A field-based case-control study was conducted to assess the strength of 
      association of porcine circovirus type 2 (PCV2) and some major swine viruses with 
      postweaning multisystemic wasting syndrome (PMWS). Cases were defined as 
      individual pigs with a clinical history of progressive weight loss and 
      histopathological lesions characteristic of PMWS. Controls were pigs without 
      clinical signs and histopathological lesions typical of PMWS. A total of 31 cases 
      and 56 controls was identified from diagnostic submissions. Serum and various 
      tissues were collected from all animals and assayed for PCV, porcine reproductive 
      and respiratory syndrome virus (PRRSV), porcine parvovirus, porcine enterovirus 
      types 1-3, swine influenza virus, porcine respiratory coronavirus, transmissible 
      gastroenteritis virus, porcine endogenous retrovirus, porcine lymphotropic 
      herpesvirus type 1, and bovine viral diarrhea virus. The proportion of case and 
      control pigs positive for each virus was determined and statistically compared 
      for determining the strength of the association that each virus had with PMWS 
      individually or in combinations. Porcine circovirus type 2 had the strongest 
      association (OR = 9.3, P = 0.006) with PMWS among the viruses tested for. Risk 
      for PWMS was much higher (OR = 31.2, P = 0.0009) if the animal was concurrently 
      infected with PCV2 and PRRSV, suggesting that development of PMWS may be enhanced 
      by cofactor(s). Because PCV2 was also found in 62.5% of the controls, PCV2 from 5 
      cases and 4 controls were selected and genetically compared. No significant 
      genetic difference was observed between PCV2 from PMWS and control pigs.
FAU - Pogranichniy, Roman M
AU  - Pogranichniy RM
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames 50011, USA.
FAU - Yoon, Kyoung-Jin
AU  - Yoon KJ
FAU - Harms, Perry A
AU  - Harms PA
FAU - Sorden, Steven D
AU  - Sorden SD
FAU - Daniels, Michael
AU  - Daniels M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Case-Control Studies
MH  - Circoviridae Infections
MH  - Circovirus/genetics/*pathogenicity
MH  - DNA Primers
MH  - DNA, Viral/*analysis
MH  - Odds Ratio
MH  - Polymerase Chain Reaction/veterinary
MH  - Porcine respiratory and reproductive syndrome virus/genetics
MH  - Risk Factors
MH  - Swine
MH  - Swine Diseases/*virology
MH  - Wasting Syndrome/*veterinary/*virology
MH  - Weaning
EDAT- 2002/11/09 04:00
MHDA- 2003/02/26 04:00
CRDT- 2002/11/09 04:00
PHST- 2002/11/09 04:00 [pubmed]
PHST- 2003/02/26 04:00 [medline]
PHST- 2002/11/09 04:00 [entrez]
AID - 10.1177/104063870201400601 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2002 Nov;14(6):449-56. doi: 10.1177/104063870201400601.