PMID- 12424796
OWN - NLM
STAT- MEDLINE
DCOM- 20030116
LR  - 20131121
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 59
IP  - 4
DP  - 2002 Nov 15
TI  - Lifespan extension by caloric restriction: an aspect of energy metabolism.
PG  - 325-30
AB  - Caloric restriction (CR) may retard aging processes and extend lifespan in 
      organisms by altering energy-metabolic pathways. In CR rodents, glucose influx 
      into tissues is not reduced, as compared with control animals fed ad libitum 
      (AL), although plasma concentrations of glucose and insulin are lower. Gene 
      expression profiles in rodents have suggested that CR promotes gluconeogenesis 
      and fatty acid biosynthesis in skeletal muscle. In the liver, CR promotes 
      gluconeogenesis but decreases fatty acid synthesis and glycolysis. In lower 
      organisms such as yeasts and nematodes, incomplete blocks in steps of 
      insulin/insulin-like growth factor-1 (IGF-1) signal pathway extend lifespan. The 
      life-prolonging effect of CR in yeasts requires NPT1 and SIR2 genes, both of 
      which relate to sensing energy status and silencing genes. These findings stress 
      the substantial role of energy metabolism on CR. Future studies on metabolic 
      adaptation and gene silencing with regard to lower caloric intake will be 
      warranted to understand the mechanisms of the anti-aging and life-prolonging 
      effects of CR.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Yamaza, Haruyoshi
AU  - Yamaza H
AD  - Department of Respiratory and Digestive Medicine, Nagasaki University School of 
      Medicine, Nagasaki City 852-8523, Japan. hyamaza@net.nagasaki-u.ac.jp
FAU - Chiba, Takuya
AU  - Chiba T
FAU - Higami, Yoshikazu
AU  - Higami Y
FAU - Shimokawa, Isao
AU  - Shimokawa I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Aging/metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - *Energy Metabolism
MH  - Gene Expression Profiling
MH  - Genome
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/physiology
MH  - Insulin-Like Growth Factor I/physiology
RF  - 54
EDAT- 2002/11/09 04:00
MHDA- 2003/01/17 04:00
CRDT- 2002/11/09 04:00
PHST- 2002/11/09 04:00 [pubmed]
PHST- 2003/01/17 04:00 [medline]
PHST- 2002/11/09 04:00 [entrez]
AID - 10.1002/jemt.10212 [doi]
PST - ppublish
SO  - Microsc Res Tech. 2002 Nov 15;59(4):325-30. doi: 10.1002/jemt.10212.