PMID- 12426055
OWN - NLM
STAT- MEDLINE
DCOM- 20030129
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 956
IP  - 1
DP  - 2002 Nov 22
TI  - Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid 
      lesions of the ventral hippocampus.
PG  - 126-35
AB  - Increasing evidence suggests that schizophrenia is a neurodevelopmental disorder 
      with a progressive course characterized by worsening of symptoms and 
      morphological alterations within the brain. This suggests that a 
      neurodegenerative component may exist in schizophrenia. The role of brain-derived 
      neurotrophic factor (BDNF) in neurodevelopment, cell viability and synaptic 
      plasticity led to the investigation of BDNF as a potential candidate molecule in 
      the pathophysiology of schizophrenia. BDNF mRNA was examined by in situ 
      hybridization in the prefrontal cortex and hippocampus of animals with neonatal 
      ibotenic acid lesions of the ventral hippocampus, a putative neurodevelopmental 
      animal model of schizophrenia. Results demonstrate that animals with neonatal 
      ibotenic acid lesions of the ventral hippocampus have reduced basal levels of 
      BDNF mRNA. It is possible that alterations in this trophic factor render animals 
      more susceptible to neurodegenerative insults.
FAU - Ashe, Paula C
AU  - Ashe PC
AD  - Department of Psychiatry, University of Saskatchewan, 103 Wiggins Road, 
      Saskatchewan, S7N 5E4, Saskatoon, Canada. paula.ashe@nrc.ca
FAU - Chlan-Fourney, Jennifer
AU  - Chlan-Fourney J
FAU - Juorio, Augusto V
AU  - Juorio AV
FAU - Li, Xin-Min
AU  - Li XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (RNA, Messenger)
RN  - 2552-55-8 (Ibotenic Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain Injuries/*chemically induced
MH  - Brain-Derived Neurotrophic Factor/drug effects/genetics/*metabolism
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - *Gene Expression Regulation
MH  - Hippocampus/drug effects/injuries/*metabolism/pathology
MH  - Ibotenic Acid/*pharmacology
MH  - In Situ Hybridization
MH  - Male
MH  - Prefrontal Cortex/drug effects/metabolism/pathology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Schizophrenia/physiopathology
MH  - Stress, Physiological
EDAT- 2002/11/12 04:00
MHDA- 2003/01/30 04:00
CRDT- 2002/11/12 04:00
PHST- 2002/11/12 04:00 [pubmed]
PHST- 2003/01/30 04:00 [medline]
PHST- 2002/11/12 04:00 [entrez]
AID - S0006899302031761 [pii]
AID - 10.1016/s0006-8993(02)03176-1 [doi]
PST - ppublish
SO  - Brain Res. 2002 Nov 22;956(1):126-35. doi: 10.1016/s0006-8993(02)03176-1.