PMID- 12426184
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 21
IP  - 11
DP  - 2001
TI  - Association of epileptiform activity with neuronal death in the CA3 subfield of 
      the hippocampus following focally evoked limbic seizures.
PG  - 831-833
AB  - OBJECTIVE: To investigate the relationnship between epileptiform activity and 
      cell death in the CA3 subfield of hippocampus following focally evoked limbic 
      seizures through a quantitative study. METHODS: Wistar rats used in this study 
      received intra-amygdaloid injection of kainic acid to induce type epileptiform 
      activity of different duration with continuous electroencephalographic (EEG) 
      monitoring. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling 
      (TUNEL) was used to detect apoptotic cells. The number of CA3 neurons survived 
      and TUNEL-positive cells were counted to estimate the number of necrotic cells. 
      RESULTS: Epileptiform activity induced necrosis in the major form of apoptosis of 
      the cells in CA3 subfield of the hippocampus following focally evoked limbic 
      seizures. The longer the type epileptiform activity lasted, the less neurons 
      survived, with consequent increase in the number of both necrotic and apoptotic 
      cells. CONCLUSION: Prolongation of type IV seizures dose-dependently causes 
      increase in apoptotic and necrotic cells in CA3 subfield of the hippocampus.
FAU - Qi, Song-Tao
AU  - Qi ST
AD  - Department of Neurosurgery, Nanfang Hospital, First Military Medical University, 
      Guangzhou, 510515, China.
FAU - Huang, Li-Jin
AU  - Huang LJ
FAU - Wang, Ke-Wan
AU  - Wang KW
FAU - Kong, Wei-Dun
AU  - Kong WD
FAU - Fang, Lu-Xiong
AU  - Fang LX
FAU - Peng, Lin
AU  - Peng L
FAU - Huang, Shen-Ping
AU  - Huang SP
FAU - Feng, Wen-Fen
AU  - Feng WF
FAU - Zhang, Xi-An
AU  - Zhang XA
LA  - eng
PT  - Journal Article
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
EDAT- 2002/11/12 04:00
MHDA- 2002/11/12 04:00
CRDT- 2002/11/12 04:00
PHST- 2002/11/12 04:00 [pubmed]
PHST- 2002/11/12 04:00 [medline]
PHST- 2002/11/12 04:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2001;21(11):831-833.