PMID- 12427368
OWN - NLM
STAT- MEDLINE
DCOM- 20030505
LR  - 20211203
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 4
IP  - 6
DP  - 2002 Dec
TI  - The role of infection in the pathogenesis of spondyloarthropathies with special 
      reference to human leukocyte antigen-B27.
PG  - 518-24
AB  - Spondyloarthropathies consist of many inflammatory diseases that are closely 
      associated with human leukocyte antigen (HLA)-B27. One of these diseases is 
      reactive arthritis (ReA), which is a joint inflammation that occurs after 
      infections that are caused by certain gram-negative bacteria. The importance of 
      these infections as causative agents of ReA has been clearly established. It is 
      not clear, however, whether these infections contribute to the development of 
      other forms of spondyloarthropathies. The exact mechanism by which HLA-B27 
      influences disease susceptibility in spondyloarthropathies remains to be 
      determined. The role of HLA-B27 as an antigen-presenting molecule is certainly 
      important in the pathogenesis of these diseases; however, recent data indicate 
      that this molecule may exhibit other functions unrelated to antigen presentation, 
      which may be important in the pathogenesis of ReA. In this paper, the authors 
      summarize the current knowledge of the role of infection in the 
      spondyloarthropathies.
FAU - Penttinen, Markus A
AU  - Penttinen MA
AD  - Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, Turku 
      FIN-20520, Finland. markus.penttinen@utu.fi
FAU - Liu, Yi
AU  - Liu Y
FAU - Granfors, Kaisa
AU  - Granfors K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
SB  - IM
MH  - Arthritis, Reactive/*etiology/immunology
MH  - Gram-Negative Bacterial Infections/*complications/immunology
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Prohibitins
MH  - Spondylarthropathies/*etiology/immunology/physiopathology
MH  - T-Lymphocytes/immunology
RF  - 50
EDAT- 2002/11/13 04:00
MHDA- 2003/05/06 05:00
CRDT- 2002/11/13 04:00
PHST- 2002/11/13 04:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2002/11/13 04:00 [entrez]
AID - 10.1007/s11926-002-0060-7 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2002 Dec;4(6):518-24. doi: 10.1007/s11926-002-0060-7.