PMID- 12427394
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20190822
IS  - 0020-7292 (Print)
IS  - 0020-7292 (Linking)
VI  - 79
IP  - 2
DP  - 2002 Nov
TI  - Cytomegalovirus infection in pregnancy.
PG  - 111-6
AB  - OBJECTIVES: To investigate the effects of intrauterine human cytomegalovirus 
      (HCMV) infection on pregnancy outcomes and infant development. METHODS: The study 
      group consisted of the HCMV-IgM-positive offspring of 75 pregnant women, and a 
      control group of the non-infected offspring of 73 pregnant women. Chorionic 
      villi, amnionic fluid, and umbilical blood were obtained to detect HCMV-late mRNA 
      with a reverse transcriptase-polymerase chain reaction (RT-PCR) assay. The 
      pregnancy outcomes were followed up. For all offspring, neurological development 
      was evaluated with neurosonography, audiologic development with the brainstem 
      auditory evoked potential (BAEP), and psychomotor development with the Beyley 
      Scale of Infant Development (BSID). RESULTS: In the study group the positive rate 
      of late mRNA was 50% in the chorionic villi and 67.65% in the amnionic fluid and 
      the umbilical blood; the incidence of abnormal pregnancy outcomes (abortion, 
      preterm delivery, stillbirth, etc.) was much higher than in the control group 
      (40% vs. 6.57%; chi(2)=24.06; P=0.001); the abnormal rate of neurosonography 
      results at birth and 3 months after birth was higher in the study group than in 
      the control group (P<0.05), as were BAEP values 4 months after birth 
      (chi(2)=8.960; P=0.003). Scores for the Infant Mental Development Index (MDI) 
      were apparently lower than in the control group. When congenitally infected 
      children were tested at the age of 5.5-6.5 years with the Wechsler Preschool and 
      Primary Scale of Intelligence (WPPSI), their rate of mental retardation was still 
      found to be approximately 20%. CONCLUSIONS: Intrauterine HCMV infection is 
      closely related to abnormal pregnancy outcomes, infant neurological damage, 
      mental retardation, and hearing loss.
FAU - Wen, L Z
AU  - Wen LZ
AD  - Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China. 
      cheny18@public.wh.hb.cn
FAU - Xing, W
AU  - Xing W
FAU - Liu, L Q
AU  - Liu LQ
FAU - Ao, L M
AU  - Ao LM
FAU - Chen, S H
AU  - Chen SH
FAU - Zeng, W J
AU  - Zeng WJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Abortion, Spontaneous/etiology
MH  - Adult
MH  - Brain Diseases/diagnostic imaging
MH  - Case-Control Studies
MH  - Cytomegalovirus Infections/*transmission
MH  - Female
MH  - Fetal Death/etiology
MH  - Fetus/abnormalities
MH  - Humans
MH  - *Infectious Disease Transmission, Vertical
MH  - Intellectual Disability/etiology
MH  - Obstetric Labor, Premature/etiology
MH  - Pregnancy
MH  - *Pregnancy Complications, Infectious
MH  - *Pregnancy Outcome
MH  - RNA, Messenger/blood
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ultrasonography
EDAT- 2002/11/13 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/11/13 04:00
PHST- 2002/11/13 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/11/13 04:00 [entrez]
AID - S0020729202002394 [pii]
AID - 10.1016/s0020-7292(02)00239-4 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2002 Nov;79(2):111-6. doi: 10.1016/s0020-7292(02)00239-4.