PMID- 12429205
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20220223
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 177
IP  - 1
DP  - 2002 Sep
TI  - Suppression of insult-induced neurogenesis in adult rat brain by brain-derived 
      neurotrophic factor.
PG  - 1-8
AB  - In mammals, including humans, the subventricular zone of the lateral ventricle 
      and the subgranular zone of the dentate gyrus contain neural stem cells, which 
      continue to proliferate even in adulthood and give rise to new neurons. 
      Neurogenesis in these areas is enhanced by brain insults. Brain-derived 
      neurotrophic factor (BDNF) promotes neuronal survival and differentiation during 
      the development of the nervous system. In the adult intact brain, BDNF 
      administration in the lateral ventricle or ventricular zone stimulates 
      neurogenesis in several forebrain areas. Here we show that intrahippocampal 
      transduction of recombinant adeno-associated virus carrying the BDNF gene giving 
      rise to levels of BDNF protein sufficient to induce a functional response 
      inhibits the formation of new dentate granule cells triggered by global forebrain 
      ischemia in rats. Our data indicate that long-term delivery of a neurotrophic 
      factor, which is considered as a novel neuroprotective strategy for human brain 
      diseases, may attenuate intrinsic neuroregenerative responses.
FAU - Larsson, Elin
AU  - Larsson E
AD  - Section of Restorative Neurology, Wallenberg Neuroscience Center, University 
      Hospital, BMC A-11 SE-221 84, Lund, Sweden.
FAU - Mandel, Ronald J
AU  - Mandel RJ
FAU - Klein, Ronald L
AU  - Klein RL
FAU - Muzyczka, Nicholas
AU  - Muzyczka N
FAU - Lindvall, Olle
AU  - Lindvall O
FAU - Kokaia, Zaal
AU  - Kokaia Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Growth Inhibitors)
SB  - IM
MH  - Adenoviridae/genetics/physiology
MH  - Animals
MH  - Brain/cytology/metabolism/*physiology
MH  - Brain Ischemia/etiology/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage/biosynthesis/genetics
MH  - Cell Survival/genetics/physiology
MH  - Growth Inhibitors/*administration & dosage/biosynthesis/genetics
MH  - Hippocampus/cytology/metabolism/physiology
MH  - Male
MH  - Nerve Regeneration/genetics/physiology
MH  - Neural Inhibition/genetics/*physiology
MH  - Neurons/cytology/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Stem Cells/cytology/drug effects
MH  - Transduction, Genetic
EDAT- 2002/11/14 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/11/14 04:00
PHST- 2002/11/14 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/11/14 04:00 [entrez]
AID - S0014488602979926 [pii]
AID - 10.1006/exnr.2002.7992 [doi]
PST - ppublish
SO  - Exp Neurol. 2002 Sep;177(1):1-8. doi: 10.1006/exnr.2002.7992.