PMID- 12430846
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20191025
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 76 Suppl 1
DP  - 2002 Aug
TI  - New strategies for BMT and organ transplantation.
PG  - 161-4
AB  - Bone marrow transplantation (BMT) is now one of the most powerful strategies for 
      the treatment of hematologic disorders (leukemia, aplastic anemia, etc), 
      congenital immunodeficiencies, metabolic disorders, and also autoimmune diseases. 
      Using various autoimmune-prone mice, we have previously shown that conventional 
      allogeneic (allo) BMT can be used to treat a range of autoimmune diseases. We 
      have very recently established new strategies for BMT and organ grafts. For BMT, 
      to minimize the contamination of BMCs with T cells from the peripheral blood, we 
      developed, using cynomolgus monkeys, a "Perfusion Method" to replace the 
      conventional aspiration method for collecting bone marrow cells (BMCs). We 
      injected the BMCs collected this way directly into the bone marrow cavity of 
      recipients that had received fractionated irradiation (intra-bone marrow [IBM] 
      injection). This "IBM-BMT" was found to be effective in treating autoimmune 
      diseases in radiation-sensitive and chimeric-resistant MRL/lpr mice. in addition, 
      this strategy was found to be applicable for the transplantation of organs, such 
      as the skin and pancreas islets in mice and rats. We believe that these 
      strategies for BMT and organ transplantation herald a new era in transplantation.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - First Department of Pathology, Regeneration Research Center for Intractable 
      Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/therapy
MH  - Bone Marrow Transplantation/*methods/trends
MH  - Humans
MH  - Injections
MH  - Organ Transplantation/*methods/trends
MH  - Perfusion
MH  - Transplantation, Homologous/methods/trends
RF  - 31
EDAT- 2002/11/15 04:00
MHDA- 2003/07/18 05:00
CRDT- 2002/11/15 04:00
PHST- 2002/11/15 04:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2002/11/15 04:00 [entrez]
AID - 10.1007/BF03165237 [doi]
PST - ppublish
SO  - Int J Hematol. 2002 Aug;76 Suppl 1:161-4. doi: 10.1007/BF03165237.