PMID- 12431191
OWN - NLM
STAT- MEDLINE
DCOM- 20030611
LR  - 20211203
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - 5
DP  - 2002 Oct
TI  - Serum immunoglobulin E levels in human immunodeficiency virus-infected children 
      with pneumonia.
PG  - 328-33
AB  - Elevated serum immunoglobulin E (IgE) levels have been reported in association 
      with human immunodeficiency virus (HIV) infection in adults, but there is little 
      information in children. The aim of the present study was to compare serum IgE 
      levels in HIV-positive and -negative children hospitalized with pneumonia in 
      South Africa and to investigate whether IgE may be useful as a marker of specific 
      infections or prognosis in HIV-infected children. History, examination, blood 
      tests, and induced sputum or bronchoalveolar lavage were carried out. Of 122 
      children [45% female, median age 8 months (3-20 months)], 81 were infected with 
      HIV. A history of allergy or asthma was present in three children (two of whom 
      were HIV positive). Serum IgE was higher in HIV-infected children [83 (33-147) 
      vs. 29 (6-113) IU/l; p = 0.011] as was immunoglobulin G (IgG) [49 (37-63) vs. 
      27.5 (23-34) g/l; p < 0.001]. CD4 lymphocytes [600 (330-1,210) vs. 1,900 
      (1,500-3,030) cells/ micro l], percentage CD4 cells [13.6 (9.4-20.3) vs. 40.1 
      (31.1-44.9)] and CD4 : CD8 ratio [0.3 (0.2-0.4) vs. 2 (1.4-2.8)] were lower in 
      HIV-positive children (p < 0.001 for all). Bacteremia occurred in 12 (10%) 
      children; other specific pathogens identified included Mycobacterium tuberculosis 
      in eight (7%) and Pneumocystis carinii in nine (7%). There was no correlation 
      with CD4 count, CD4 : CD8 ratio, or the presence of specific pathogens, and IgE 
      level. In-hospital mortality (11%) did not correlate with IgE levels. 
      HIV-infected children with pneumonia have higher serum IgE compared with 
      seronegative patients. In HIV-positive children, IgE levels did not correlate 
      with the degree of immunosuppression or with outcome.
FAU - Zar, Heather J
AU  - Zar HJ
AD  - Department of Paediatrics and Child Health, Red Cross Children's Hospital, 
      University of Cape Town, Cape Town, South Africa. heather@rmh.uct.ac.za
FAU - Latief, Zeino
AU  - Latief Z
FAU - Hughes, Jane
AU  - Hughes J
FAU - Hussey, Gregory
AU  - Hussey G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Bacteremia/blood/immunology/mortality
MH  - Biomarkers/blood
MH  - Cytomegalovirus
MH  - Eosinophils/immunology
MH  - Female
MH  - HIV/*immunology
MH  - HIV Infections/*blood/*immunology/mortality
MH  - HIV Seronegativity/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood/*immunology
MH  - Immunoglobulin G/blood/immunology
MH  - Immunosuppression Therapy
MH  - Infant
MH  - Infant Welfare
MH  - Leukocyte Count
MH  - Male
MH  - Pneumonia/*blood/*immunology/mortality
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Simplexvirus
MH  - South Africa
MH  - Survival Analysis
MH  - Tuberculosis, Pulmonary/blood/immunology/mortality
EDAT- 2002/11/15 04:00
MHDA- 2003/06/12 05:00
CRDT- 2002/11/15 04:00
PHST- 2002/11/15 04:00 [pubmed]
PHST- 2003/06/12 05:00 [medline]
PHST- 2002/11/15 04:00 [entrez]
AID - pai2o019 [pii]
AID - 10.1034/j.1399-3038.2002.02019.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002 Oct;13(5):328-33. doi: 
      10.1034/j.1399-3038.2002.02019.x.