PMID- 12433448
OWN - NLM
STAT- MEDLINE
DCOM- 20030520
LR  - 20190910
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 249
IP  - 1-2
DP  - 2002 Dec 5
TI  - 6-O-alpha-(4-O-alpha-D-glucuronyl)-D-glucosyl-beta-cyclodextrin: solubilizing 
      ability and some cellular effects.
PG  - 199-209
AB  - Some physicochemical and biopharmaceutical properties of a new branched 
      cyclodextrin, 6-O-alpha-(4-O-alpha-D-glucuronyl)-D-glucosyl-beta-cyclodextrin 
      (GUG-beta-CyD), were investigated. The interaction of GUG-beta-CyD with drugs was 
      studied by spectroscopic and solubility methods, and compared with those of 
      parent beta-CyD and 6-O-alpha-maltosyl-beta-CyD (G(2)-beta-CyD). The hemolytic 
      activity of GUG-beta-CyD on rabbit erythrocytes was lower than those of beta-CyD 
      and G(2)-beta-CyD. GUG-beta-CyD and G(2)-beta-CyD showed negligible cytotoxicity 
      on Caco-2 cells up to at least 0.1 M. The inclusion ability of GUG-beta-CyD to 
      neutral and acidic drugs was comparable to or slightly smaller than those of 
      beta-CyD and G(2)-beta-CyD, probably because of a steric hindrance of the 
      branched sugar. On the other hand, GUG-beta-CyD showed greater affinity for the 
      basic drugs, compared with beta-CyD and G(2)-beta-CyD, owing to an electrostatic 
      interaction of its carboxylate anion with positive charge of basic drugs. Thus, 
      GUG-beta-CyD may be useful as a safe solubilizing agent particularly for basic 
      drugs.
FAU - Tavornvipas, Sumitra
AU  - Tavornvipas S
AD  - Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 
      Kumamoto 862-0973, Japan.
FAU - Hirayama, Fumitoshi
AU  - Hirayama F
FAU - Arima, Hidetoshi
AU  - Arima H
FAU - Uekama, Kaneto
AU  - Uekama K
FAU - Ishiguro, Toshihiro
AU  - Ishiguro T
FAU - Oka, Masahide
AU  - Oka M
FAU - Hamayasu, Kenichi
AU  - Hamayasu K
FAU - Hashimoto, Hitoshi
AU  - Hashimoto H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Cyclodextrins)
RN  - 0 (Oligosaccharides)
RN  - 0 (cyclomaltoheptaosyl-(6-1)-glucopyranosyl-(4-1)-glucopyranosiduronic acid)
SB  - IM
MH  - Animals
MH  - Caco-2 Cells/drug effects/physiology
MH  - Cyclodextrins/*chemistry/*pharmacology
MH  - Humans
MH  - Oligosaccharides/*chemistry/*pharmacology
MH  - Rabbits
MH  - Solubility
EDAT- 2002/11/16 04:00
MHDA- 2003/05/21 05:00
CRDT- 2002/11/16 04:00
PHST- 2002/11/16 04:00 [pubmed]
PHST- 2003/05/21 05:00 [medline]
PHST- 2002/11/16 04:00 [entrez]
AID - S0378517302005379 [pii]
AID - 10.1016/s0378-5173(02)00537-9 [doi]
PST - ppublish
SO  - Int J Pharm. 2002 Dec 5;249(1-2):199-209. doi: 10.1016/s0378-5173(02)00537-9.