PMID- 12437548
OWN - NLM
STAT- MEDLINE
DCOM- 20030409
LR  - 20190910
IS  - 0736-8046 (Print)
IS  - 0736-8046 (Linking)
VI  - 19
IP  - 6
DP  - 2002 Nov-Dec
TI  - A prospective case control study of the association of Gianotti-Crosti syndrome 
      with human herpesvirus 6 and human herpesvirus 7 infections.
PG  - 492-7
AB  - Gianotti-Crosti syndrome (GCS) is known to be associated with hepatitis B and 
      Epstein-Barr virus (EBV) infections. Apart from a single case report based on 
      serology alone, there are no published data on an association between GCS and 
      human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) primary infections or 
      reactivations. Our aim was to investigate the association between GCS and HHV-6 
      and HHV-7 infections. Ten patients diagnosed with GCS at a primary care practice 
      over an 18-month period were recruited. Controls were age- and sex-matched 
      patients with unrelated symptoms requiring venepuncture for other indications. 
      Blood specimens were collected from patients and controls at presentation, and 
      from patients 4 weeks later. Virologic evidence of HHV-6 and HHV-7 infection was 
      sought in peripheral blood leukocytes and plasma using polymerase chain reaction 
      (PCR) for viral DNA, reverse transcriptase polymerase chain reaction (RT-PCR) for 
      HHV-6 U91 mRNA transcripts, and serology. Serology for EBV and hepatitis B virus 
      was done. In contrast to the 10 controls, 2 patients (both infants) with 
      clinically diagnosed GCS had evidence of active HHV-6 infection. This was 
      demonstrated by detection of viral DNA in the absence of antibody in the acute 
      plasma specimens and HHV-6 DNA viral loads of more than 5.3 log10 genome copies/5 
      microl in the whole blood specimens, a profile previously shown to be diagnostic 
      of recent primary HHV-6 infection. None of the patients had evidence of recent 
      EBV or hepatitis B infection. We conclude that primary HHV-6 infection may be 
      associated with GCS in some infants.
FAU - Chuh, Antonio An Tung
AU  - Chuh AA
AD  - Department of Medicine, University of Hong Kong and Queen Mary Hospital, 
      Pokfulam, Hong Kong, SAR. achuh@iohk.com
FAU - Chan, Henry Hin Lee
AU  - Chan HH
FAU - Chiu, Susan Shui Seng
AU  - Chiu SS
FAU - Ng, Hoi Yee
AU  - Ng HY
FAU - Peiris, Joseph Sriyal Malik
AU  - Peiris JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Acrodermatitis/*virology
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exanthema Subitum/*complications
MH  - Female
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Roseolovirus Infections/*complications
MH  - Statistics, Nonparametric
EDAT- 2002/11/20 04:00
MHDA- 2003/04/10 05:00
CRDT- 2002/11/20 04:00
PHST- 2002/11/20 04:00 [pubmed]
PHST- 2003/04/10 05:00 [medline]
PHST- 2002/11/20 04:00 [entrez]
AID - 0217 [pii]
AID - 10.1046/j.1525-1470.2002.00217.x [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2002 Nov-Dec;19(6):492-7. doi: 
      10.1046/j.1525-1470.2002.00217.x.