PMID- 12438971
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20220409
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 74
IP  - 8
DP  - 2002 Oct 27
TI  - All chronic rejection failures of kidney transplants were preceded by the 
      development of HLA antibodies.
PG  - 1192-4
AB  - BACKGROUND: Recent studies show that almost all patients who have rejected a 
      kidney transplant had human leukocyte antigen (HLA) antibodies. In this study, we 
      sought to determine whether patients develop HLA antibodies before chronic 
      rejection. METHODS: For the past 8 years, 139 patients who had undergone kidney 
      transplantation were systematically examined, using an enzyme-linked 
      immunosorbent assay-based method, for the development of class-I and class-II HLA 
      antibodies 3 months, 6 months, and yearly after transplantation. Chronic 
      rejection was diagnosed by biopsy. RESULTS: Among 29 patients with chronic 
      rejection, 100% of the patients had HLA antibodies before rejection. Of these 
      patients, 14 patients developed antibodies de novo. In contrast, among 110 
      patients with stable function, 27% of the patients developed HLA antibodies 
      posttransplant (P<0.001). CONCLUSIONS: HLA antibodies were found in 29 
      consecutive cases of chronic rejection failures as much as one year before the 
      loss of grafts. We conclude that HLA antibodies may be a prerequisite for chronic 
      immunologic rejection.
FAU - Lee, Po-Chang
AU  - Lee PC
AD  - Department of Surgery, Medical College, University Hospital, National Cheng Kung 
      University, 138 Sheng-Li Road, Tainan, Taiwan 704. pochang@mail.ncku.edu.tw
FAU - Terasaki, Paul I
AU  - Terasaki PI
FAU - Takemoto, Steven K
AU  - Takemoto SK
FAU - Lee, Po-Huang
AU  - Lee PH
FAU - Hung, Chung-Jye
AU  - Hung CJ
FAU - Chen, Yi-Lin
AU  - Chen YL
FAU - Tsai, Alen
AU  - Tsai A
FAU - Lei, Huan-Yao
AU  - Lei HY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Curr Surg. 2005 May-Jun;62(3):294-9. PMID: 15890211
MH  - Autoantibodies/*blood
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graft Rejection/etiology/*immunology
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Treatment Failure
EDAT- 2002/11/20 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/11/20 04:00
PHST- 2002/11/20 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/11/20 04:00 [entrez]
AID - 10.1097/00007890-200210270-00025 [doi]
PST - ppublish
SO  - Transplantation. 2002 Oct 27;74(8):1192-4. doi: 10.1097/00007890-200210270-00025.