PMID- 12441056
OWN - NLM
STAT- MEDLINE
DCOM- 20021219
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 36
IP  - 4
DP  - 2002 Nov 14
TI  - Localized synaptic potentiation by BDNF requires local protein synthesis in the 
      developing axon.
PG  - 675-88
AB  - Brain-derived neurotrophic factor (BDNF) is known to promote neuronal survival, 
      guide axonal pathfinding, and participate in activity-dependent synaptic 
      plasticity. In Xenopus nerve-muscle cultures, localized contact of a single 
      BDNF-coated bead with the presynaptic axon resulted in potentiation of 
      transmitter secretion at the developing synapses, but only when the bead was 
      placed within 60 microm from the synapse. The localized potentiation induced by 
      BDNF is accompanied by a persistent local elevation of [Ca(2+)](i) in the axon 
      and requires constitutive presynaptic protein translation, even for axons severed 
      from the cell body. Thus, presynaptic local TrkB signaling and protein synthesis 
      allow a localized source of BDNF to potentiate transmitter secretion from nearby 
      synapses, a property suited for spatially restricted synaptic modification by 
      neurotrophins.
FAU - Zhang, Xiao hui
AU  - Zhang Xh
AD  - Division of Neurobiology, Department of Molecular and Cell Biology, University of 
      California, Berkeley, Berkeley, CA 94720, USA.
FAU - Poo, Mu-ming
AU  - Poo MM
LA  - eng
GR  - NS 37831/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - N9YNS0M02X (Acetylcholine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
CIN - Neuron. 2002 Nov 14;36(4):549-50. PMID: 12441043
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Calcium/metabolism
MH  - Calcium Signaling/drug effects/physiology
MH  - Cell Differentiation/drug effects/*physiology
MH  - Embryo, Nonmammalian
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Microspheres
MH  - Motor Neurons/cytology/drug effects/metabolism
MH  - Muscle, Skeletal/embryology/innervation
MH  - Neuromuscular Junction/cytology/drug effects/*embryology
MH  - Presynaptic Terminals/drug effects/*metabolism/ultrastructure
MH  - Receptor, trkB/antagonists & inhibitors/*biosynthesis
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Xenopus laevis
EDAT- 2002/11/21 04:00
MHDA- 2002/12/20 04:00
CRDT- 2002/11/21 04:00
PHST- 2002/11/21 04:00 [pubmed]
PHST- 2002/12/20 04:00 [medline]
PHST- 2002/11/21 04:00 [entrez]
AID - S0896627302010231 [pii]
AID - 10.1016/s0896-6273(02)01023-1 [doi]
PST - ppublish
SO  - Neuron. 2002 Nov 14;36(4):675-88. doi: 10.1016/s0896-6273(02)01023-1.