PMID- 12441912
OWN - NLM
STAT- MEDLINE
DCOM- 20031010
LR  - 20190916
IS  - 0957-5235 (Print)
IS  - 0957-5235 (Linking)
VI  - 13
IP  - 8
DP  - 2002 Dec
TI  - Thrombolytic fibrin specificity influences activated partial thromboplastin time 
      prolongation in vitro.
PG  - 725-31
AB  - Despite limited comparative data, guidelines suggest the same concomitant 
      unfractionated heparin (UFH) dose for all fibrin-specific thrombolytic agents in 
      acute myocardial infarction. Since a supratherapeutic activated partial 
      thromboplastin time (aPTT) correlates with adverse outcomes, clarifying effects 
      of various agents on aPTT are needed. The present in vitro study evaluated the 
      influence of alteplase (rt-PA), reteplase (r-PA), and tenecteplase (TNK) on aPTT 
      prolongation. Blood samples from healthy volunteers (n = 12) were treated with 
      equipotent concentrations of rt-PA, r-PA, and TNK, with and without UFH. Samples 
      of each treatment group were incubated at 37 degrees C; aPTT and fibrinogen 
      activity were measured after 4 h. Mean aPTT values for rt-PA alone and r-PA alone 
      were prolonged versus those of TNK alone (P = 0.001 for both). Combined with UFH, 
      rt-PA and r-PA increased the aPTT versus UFH alone (P < 0.05 for both). 
      Interestingly, TNK + UFH reduced the aPTT versus UFH alone (P < 0.001). A 
      negative correlation existed between fibrinogen activity and aPTT for all 
      treatments, except TNK alone. The present investigation illustrates that an agent 
      with maximal fibrin specificity (TNK) has minimal effect on the aPTT, while 
      agents with less fibrin specificity are more likely to prolong the aPTT, with and 
      without UFH present.
FAU - Tsikouris, J P
AU  - Tsikouris JP
AD  - Texas Tech University School of Pharmacy, Lubbock 79430, USA. 
      james.tsikouris@ttuhsc.edu
FAU - Ii, K C
AU  - Ii KC
FAU - Fike, D S
AU  - Fike DS
FAU - Cox, C D
AU  - Cox CD
FAU - Meyerrose, G E
AU  - Meyerrose GE
FAU - Seifert, C F
AU  - Seifert CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and 
      thrombosis
JID - 9102551
RN  - 0 (Fibrinolytic Agents)
RN  - 9001-31-4 (Fibrin)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Blood Coagulation/*drug effects
MH  - Drug Interactions
MH  - Female
MH  - Fibrin/*metabolism
MH  - Fibrinogen/metabolism
MH  - Fibrinolytic Agents/*pharmacology
MH  - Heparin/pharmacology
MH  - Humans
MH  - Male
MH  - Partial Thromboplastin Time
EDAT- 2002/11/21 04:00
MHDA- 2003/10/11 05:00
CRDT- 2002/11/21 04:00
PHST- 2002/11/21 04:00 [pubmed]
PHST- 2003/10/11 05:00 [medline]
PHST- 2002/11/21 04:00 [entrez]
AID - 10.1097/00001721-200212000-00009 [doi]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 2002 Dec;13(8):725-31. doi: 
      10.1097/00001721-200212000-00009.