PMID- 12442018
OWN - NLM
STAT- MEDLINE
DCOM- 20030117
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 21
IP  - 11
DP  - 2002 Nov
TI  - Human herpesvirus 6 infection in febrile infants ninety days of age and younger.
PG  - 996-9
AB  - BACKGROUND: The importance of human herpesvirus 6 (HHV-6) as a pathogen in 
      febrile infants </=90 days of age is unknown. OBJECTIVE: To determine whether 
      febrile infants 90 days of age and younger evaluated for sepsis have evidence of 
      HHV-6 DNA in plasma or cerebrospinal fluid (CSF). METHODS: Febrile infants </=90 
      days of age were tested for HHV-6 DNA using a real time quantitative fluorescent 
      probe polymerase chain reaction assay. RESULTS: Eighty samples from 47 infants 
      were tested for HHV-6 DNA; 5 of 47 infants (10.6%) had HHV-6 DNA in plasma. In 2 
      of the 5 infants with HHV-6 DNA in plasma, HHV-6 DNA was also detected in the 
      CSF. Both infants with evidence of HHV-6 DNA in plasma and CSF had HHV-6 Variant 
      A infection. The quantity of HHV-6 DNA detected ranged from 70 to 169,000 DNA 
      copies/ml. One infant with HHV-6 variant B infection had concomitant Escherichia 
      coli bacteremia and urinary tract infection. CONCLUSIONS: Approximately 10% of 
      febrile infants </=90 days of age evaluated for sepsis had evidence of HHV-6 
      infection. HHV-6 Variant A and B infections were seen in these young infants. 
      HHV-6 DNA was found in infants with and without another explanation for fever. 
      Quantification of viral DNA may be important in determining the relevance of 
      HHV-6 DNA in clinical specimens.
FAU - Byington, Carrie L
AU  - Byington CL
AD  - Department of Pediatrics, University of Utah, Salt Lake City, USA. 
      cbyington@med.utah.edu
FAU - Zerr, Danielle M
AU  - Zerr DM
FAU - Taggart, E William
AU  - Taggart EW
FAU - Nguy, Long
AU  - Nguy L
FAU - Hillyard, David R
AU  - Hillyard DR
FAU - Carroll, Karen C
AU  - Carroll KC
FAU - Corey, Lawrence
AU  - Corey L
LA  - eng
GR  - M01-RR00064/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Aging
MH  - DNA, Viral/blood
MH  - Female
MH  - Fever/*complications/virology
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/blood/cerebrospinal fluid/*complications/*virology
EDAT- 2002/11/21 04:00
MHDA- 2003/01/18 04:00
CRDT- 2002/11/21 04:00
PHST- 2002/11/21 04:00 [pubmed]
PHST- 2003/01/18 04:00 [medline]
PHST- 2002/11/21 04:00 [entrez]
AID - 10.1097/00006454-200211000-00004 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2002 Nov;21(11):996-9. doi: 
      10.1097/00006454-200211000-00004.