PMID- 12442791
OWN - NLM
STAT- MEDLINE
DCOM- 20030319
LR  - 20190901
IS  - 0269-7491 (Print)
IS  - 0269-7491 (Linking)
VI  - 120
IP  - 3
DP  - 2002
TI  - Endocrine effects of sublethal exposure to persistent organic pollutants (POPs) 
      on silver carp (Hypophthalmichthys molitrix).
PG  - 683-90
AB  - Silver carp (Hypophthalmichthys molitrix) samples were collected from five 
      selected sites that represent diverse levels of downgraded persistent organic 
      pollutants (POPs) contamination in Ya-Er Lake in October 1999. Hepatic 
      ethoxyresorufin-O-deethylase (EROD) and UDP glucuronosyltransferase (UDPGT) 
      activities, hepatosomatic index (HSI), hepatic retinoids, serum thyroid hormones 
      were measured. It was found that hepatic retinol and serum free 3,5,3'- 
      tetraiodothyronine (FT3) significantly increased (P < 0.01) when both hepatic 
      EROD and UDPGT activities significantly declined (P < 0.01) from pond 1 to 5 with 
      decrease in the degree of pollution. This significant negative correlation (P < 
      0.01) suggests that the persistent organochlorinated contaminants could induce 
      hepatic EROD and UDPGT activities, alter retinoid and thyroid hormone 
      homeostasis, and finally lead to the reduction of retinol and FT3, the two 
      biologically active forms of retinoids and thyroid hormone in silver carp of 
      Ya-Er Lake.
FAU - Xu, Y
AU  - Xu Y
AD  - Institute of Hydrobiology, Chinese Academy of Science, Wuhan. xuying@ihb.ac.cn
FAU - Zhang, J
AU  - Zhang J
FAU - Li, W
AU  - Li W
FAU - Schramm, K W
AU  - Schramm KW
FAU - Kettrup, A
AU  - Kettrup A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Organic Chemicals)
RN  - 0 (Water Pollutants, Chemical)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 11103-57-4 (Vitamin A)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 2.4.1.17 (Glucuronosyltransferase)
SB  - IM
MH  - Animals
MH  - Carps/*metabolism
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Endocrine System/*drug effects
MH  - Environmental Exposure
MH  - Glucuronosyltransferase/metabolism
MH  - Liver/metabolism
MH  - Organic Chemicals/*toxicity
MH  - Triiodothyronine/blood
MH  - Vitamin A/metabolism
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2002/11/22 04:00
MHDA- 2003/03/20 04:00
CRDT- 2002/11/22 04:00
PHST- 2002/11/22 04:00 [pubmed]
PHST- 2003/03/20 04:00 [medline]
PHST- 2002/11/22 04:00 [entrez]
AID - S0269-7491(02)00182-3 [pii]
AID - 10.1016/s0269-7491(02)00182-3 [doi]
PST - ppublish
SO  - Environ Pollut. 2002;120(3):683-90. doi: 10.1016/s0269-7491(02)00182-3.