PMID- 12443029
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20220321
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 48
IP  - 3
DP  - 2002 Sep
TI  - Preeclampsia: a multifactorial disease resulting from the interaction of the 
      feto-maternal HLA genotype and HCMV infection.
PG  - 176-83
AB  - PROBLEM: To clarify the possible influence of human leukocyte antigen (HLA) 
      mother-child genotypes and human cytomegalo virus (HCMV) presence on the 
      development of preeclampsia. METHODS OF STUDY: One hundred and four DNA samples 
      from mothers with preeclampsia, mothers with a normal history of pregnancies and 
      their neonates were tested by polymerase chain reaction-sequence specific 
      oligonucleotide probes (PCR-SSOP) for HLA-A, -G, -DRB1, -DQA1, -DQB1 alleles. The 
      HCMV sequences were analyzed using a PCR-SSOP method and the four primers 
      described by Chou (Chou S: J Clin Microb 1992; 30:2307-2310). RESULTS: Compared 
      with their respective controls, a significant increase of DRB1*07 among neonates 
      (P(c) = 0.05) and of DRB1*07 and/or DRB1*06 among pre-eclamptic mothers (P(c) = 
      0.003, RR = 8,5) was found. When HCMV sequences were detected in pre-eclamptic 
      mothers carrying those phenotypes the RR increased up to 40. Furthermore, the 
      fetal inheritance of a maternal HLA-G*0104 increased the risk for the appearance 
      of the disease (RR = 30; P = 0.025). CONCLUSION: The results suggest that the 
      presence of alleles HLA-G*0104, DRB1*07/06, HCMV sequences and the fetal 
      inheritance of maternal G*0104, should be considered as conditioning factors for 
      the development of preeclampsia.
FAU - Carreiras, M
AU  - Carreiras M
AD  - Escuela de Bioanalisis, Central University of Venezuela, Caracas.
FAU - Montagnani, S
AU  - Montagnani S
FAU - Layrisse, Z
AU  - Layrisse Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - *Alleles
MH  - Cytomegalovirus/genetics/*isolation & purification
MH  - Cytomegalovirus Infections/immunology/virology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant, Newborn
MH  - Polymerase Chain Reaction
MH  - Pre-Eclampsia/*genetics/immunology/*virology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
EDAT- 2002/11/22 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/11/22 04:00
PHST- 2002/11/22 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/11/22 04:00 [entrez]
AID - 10.1034/j.1600-0897.2002.01076.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2002 Sep;48(3):176-83. doi: 
      10.1034/j.1600-0897.2002.01076.x.