PMID- 12443897
OWN - NLM
STAT- MEDLINE
DCOM- 20030305
LR  - 20191106
IS  - 1286-4579 (Print)
IS  - 1286-4579 (Linking)
VI  - 4
IP  - 13
DP  - 2002 Nov
TI  - Human herpesvirus 6 and Chlamydia pneumoniae as etiologic agents in multiple 
      sclerosis - a critical review.
PG  - 1327-33
AB  - Multiple sclerosis (MS) is thought by many investigators to have an infectious 
      component, and several microorganisms have been associated with the disease 
      during the last three decades. Recent studies have implicated both human 
      herpesvirus 6 (HHV-6) and the obligate intracellular bacterium Chlamydia 
      pneumoniae in the etiology of MS. As with earlier studies of other potential 
      agents, however, evidence linking either of these organisms to the disease is 
      equivocal. In this article, we review data for and against involvement of HHV-6 
      and C. pneumoniae in MS, as well as evidence concerning auxiliary factors, such 
      as possession of the APOE epsilon4 allele, which may influence the role of these 
      organisms in pathogenesis. Further, we suggest several lines of investigation 
      that should clarify whether either or both pathogens are associated meaningfully 
      with this disease.
FAU - Swanborg, Robert H
AU  - Swanborg RH
AD  - Department Immunology, Wayne State University School of Medicine, Detroit, MI 
      48201, USA.
FAU - Whittum-Hudson, Judith A
AU  - Whittum-Hudson JA
FAU - Hudson, Alan P
AU  - Hudson AP
LA  - eng
GR  - AI-44055/AI/NIAID NIH HHS/United States
GR  - AI-44493/AI/NIAID NIH HHS/United States
GR  - NS-06985/NS/NINDS NIH HHS/United States
GR  - RG1073/RG/CSR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - France
TA  - Microbes Infect
JT  - Microbes and infection
JID - 100883508
RN  - 0 (Antigens, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antigens, Viral/cerebrospinal fluid
MH  - Autoimmunity
MH  - Child
MH  - Chlamydophila Infections/*microbiology
MH  - Chlamydophila pneumoniae/*pathogenicity
MH  - DNA, Viral/cerebrospinal fluid
MH  - Encephalitis/virology
MH  - Herpesvirus 6, Human/*pathogenicity
MH  - Humans
MH  - Infant, Newborn
MH  - Multiple Sclerosis/*microbiology/virology
MH  - Roseolovirus Infections/*virology
RF  - 41
EDAT- 2002/11/22 04:00
MHDA- 2003/03/06 04:00
CRDT- 2002/11/22 04:00
PHST- 2002/11/22 04:00 [pubmed]
PHST- 2003/03/06 04:00 [medline]
PHST- 2002/11/22 04:00 [entrez]
AID - S1286457902000096 [pii]
AID - 10.1016/s1286-4579(02)00009-6 [doi]
PST - ppublish
SO  - Microbes Infect. 2002 Nov;4(13):1327-33. doi: 10.1016/s1286-4579(02)00009-6.