PMID- 12445671
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 189
IP  - 1
DP  - 2003 Jan 10
TI  - Menin interacting proteins as clues toward the understanding of multiple 
      endocrine neoplasia type 1.
PG  - 1-10
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome 
      characterized mostly by tumors of the parathyroids, pancreas and anterior 
      pituitary. The gene responsible, MEN1, encodes Menin, a 610 aminoacid nuclear 
      protein with no sequence homology to other proteins. Although a mouse knock-out 
      model is available, the function of Menin is still elusive. Proteins of known 
      function are shown to interact with Menin: JunD, nuclear factor-KappaB, Smad3, 
      Pem, Nm23H1, glial fibrillary acidic protein, Vimentin, and probably P53. Their 
      partnership with Menin may correspond to a regulation of their activity, but 
      their relevance to the various traits of MEN1 pathogenicity is not established. 
      This raises fundamental issues on the regulation pathways implicated in this 
      complex endocrine disease.
FAU - Poisson, Ariane
AU  - Poisson A
AD  - CNRS UMR 6549, Instabilite et Alterations des Genomes, Faculte de Medecine, Nice, 
      France.
FAU - Zablewska, Barbara
AU  - Zablewska B
FAU - Gaudray, Patrick
AU  - Gaudray P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Cell Cycle
MH  - Cell Division
MH  - Disease Models, Animal
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Intermediate Filament Proteins/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*metabolism
MH  - Neoplasm Proteins/genetics/*physiology
MH  - Neuronal Plasticity
MH  - Protein Binding
MH  - *Proto-Oncogene Proteins
RF  - 55
EDAT- 2002/11/26 04:00
MHDA- 2003/01/31 04:00
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - S0304383502005098 [pii]
AID - 10.1016/s0304-3835(02)00509-8 [doi]
PST - ppublish
SO  - Cancer Lett. 2003 Jan 10;189(1):1-10. doi: 10.1016/s0304-3835(02)00509-8.