PMID- 12445721
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20220309
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 137
IP  - 1-2
DP  - 2002 Dec 2
TI  - Nucleus accumbens dopamine depletion impairs both acquisition and performance of 
      appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine 
      function.
PG  - 149-63
AB  - The involvement of mesoaccumbens dopamine in adaptive learning and behaviour is 
      unclear. For example, dopamine may act as a teaching signal to enable learning, 
      or more generally modulate the behavioural expression, or selection, of an 
      already-learned response. The present study investigated the involvement of the 
      mesoaccumbens dopamine system in a fundamental form of learning: Pavlovian 
      conditioning. In this case, the temporal association of a previously neutral 
      visual stimulus and a biologically significant unconditioned stimulus (US), 
      subsequently led to the production of the conditioned response (CR) of 
      discriminated approach behaviour directed toward the conditioned stimulus (CS+), 
      relative to a control (CS-) stimulus. 6-hydroxydopamine lesions of the nucleus 
      accumbens (NAcc), leading to approximately 80% reductions in tissue dopamine, 
      were made at varying time points in four experimental groups of rats, either 
      before or subsequent to the acquisition of the CR. NAcc dopamine depletion 
      produced long-term neuroadaptations in dopamine function 2 months after surgery, 
      and profoundly impaired discriminated Pavlovian approach regardless of when the 
      lesion was made. Thus, NAcc dopamine not only plays a role in conditioned 
      behavioural activation, but also in making the appropriate discriminated response 
      i.e. the direction of response. Further, acquisition lesions produced a far 
      greater impact on discriminated approach than performance lesions. This 
      difference in lesion-induced impairment implies that mesoaccumbens dopamine may 
      play differential roles in the learning and performance of preparatory Pavlovian 
      conditioning.
FAU - Parkinson, J A
AU  - Parkinson JA
AD  - Department of Experimental Psychology, University of Cambridge, Downing Street, 
      CB2 3EB, Cambridge, UK. jap22@cam.ac.uk
FAU - Dalley, J W
AU  - Dalley JW
FAU - Cardinal, R N
AU  - Cardinal RN
FAU - Bamford, A
AU  - Bamford A
FAU - Fehnert, B
AU  - Fehnert B
FAU - Lachenal, G
AU  - Lachenal G
FAU - Rudarakanchana, N
AU  - Rudarakanchana N
FAU - Halkerston, K M
AU  - Halkerston KM
FAU - Robbins, T W
AU  - Robbins TW
FAU - Everitt, B J
AU  - Everitt BJ
LA  - eng
GR  - G9537855/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/*physiology
MH  - Association Learning/physiology
MH  - Cerebral Cortex/physiology
MH  - Conditioning, Classical/*physiology
MH  - Corpus Striatum/physiology
MH  - Discrimination Learning/physiology
MH  - Dopamine/*physiology
MH  - Male
MH  - Motor Activity/physiology
MH  - Neural Pathways/physiology
MH  - Nucleus Accumbens/*physiology
MH  - Pattern Recognition, Visual/physiology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 2002/11/26 04:00
MHDA- 2003/03/04 04:00
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - S0166432802002917 [pii]
AID - 10.1016/s0166-4328(02)00291-7 [doi]
PST - ppublish
SO  - Behav Brain Res. 2002 Dec 2;137(1-2):149-63. doi: 10.1016/s0166-4328(02)00291-7.