PMID- 12445801
OWN - NLM
STAT- MEDLINE
DCOM- 20030613
LR  - 20220330
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 20
IP  - 2
DP  - 2002 Oct 21
TI  - The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive 
      cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human 
      gingival tissues.
PG  - 70-7
AB  - Chemokines are said to be small peptides that are chemoattractants for leukocyte 
      subpopulations within local inflammation sites. Gingival inflammation is 
      characterized by infiltration of inflammatory mononuclear cells. The point of 
      this study was to examine the presence or absence of chemokine-positive cells and 
      chemokine receptor-positive cells by means of immunohistochemical methods in 
      samples of gingival tissues obtained from patients with marginal periodontitis. 
      Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein 
      (MIP)-1alpha, MIP-1beta, (IFN-gamma)-inducible protein-10 (IP-10) and 
      RANTES-producing cells were found to be present in inflamed human gingival 
      tissues. In addition, CCR5- and CXCR3-positive cells were present. In contrast, 
      no factor expression was observed in periodontally healthy gingival tissue. Our 
      findings suggest that these chemokines may be responsible for modulating the 
      process of infectious disease such as marginal periodontitis.
FAU - Kabashima, Hiroaki
AU  - Kabashima H
AD  - Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental 
      Science, Kyushu University, Fukuoka 812-8582, Japan.
FAU - Yoneda, Masahiro
AU  - Yoneda M
FAU - Nagata, Kengo
AU  - Nagata K
FAU - Hirofuji, Takao
AU  - Hirofuji T
FAU - Maeda, Katsumasa
AU  - Maeda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (CXCR3 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR3)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/metabolism
MH  - Chemokine CXCL10
MH  - Chemokines/*metabolism
MH  - Chemokines, CXC/metabolism
MH  - Female
MH  - Gingiva/immunology
MH  - Gingivitis/*immunology/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Macrophage Inflammatory Proteins/metabolism
MH  - Male
MH  - Middle Aged
MH  - Periodontitis/immunology
MH  - Receptors, CCR5/metabolism
MH  - Receptors, CXCR3
MH  - Receptors, Chemokine/*metabolism
EDAT- 2002/11/26 04:00
MHDA- 2003/06/14 05:00
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/06/14 05:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - S104346660291985X [pii]
AID - 10.1006/cyto.2002.1985 [doi]
PST - ppublish
SO  - Cytokine. 2002 Oct 21;20(2):70-7. doi: 10.1006/cyto.2002.1985.